The University of North Carolina at Chapel Hill

Princeton University

Imclone Systems, Inc.

John N Snouwaert

Dana M Fowlkes

Charles T Tackney

Susan M Skelly

Muteins of IL-6 and truncated IL-6 are prepared by recombinant DNA techniques. In the muteins, the cysteine residues that occur at positions, or at positions corresponding to positions, 45 and 51 of mature, native IL-6 have been replaced by other amino acids. The cysteine residues that occur at positions, or at positions corresponding to positions, 74 and 84 are retained. The molecule has biological activity that is at least comparable to that of native IL-6.

Growing community of inventors

Carrboro, NC, United States of America

John N Snouwaert