Chiesi Farmaceutici S.p.a.

John Montana

Monique Bodil Van Niel

Harry Finch

Bohdan Waszkowycz

Chi-Kit Woo

Jamie Knight

Compounds of formula (I) are inhibitors of p38 MAP kinase, useful as anti-inflammatory agents in the treatment of inter alia, diseases of the respiratory tract wherein; Ris C-Calkyl, C-Ccycloalkyl, phenyl which is optionally substituted, 5- or 6 membered monocyclic heteroaryl which is optionally substituted, or a radical of formula (II) wherein n is 1 or 2, and Rand Rare independently H or C-Calkyl, or Rand Rtaken together with the nitrogen to which they are attached form a 6-membered heterocyclic ring optionally containing a further heteroatom selected from N and O; Y is &#x2014;O&#x2014; or &#x2014;S(O)&#x2014; wherein p is 0, 1 or 2; A is an optionally substituted divalent arylene radical, or a mono- or bicyclic heteroarylene radical, or a C-Cdivalent cycloalkylene radical having 5 or 6 ring atoms, or a piperidinylene radical wherein the ring nitrogen is linked to RNHC(&#x2550;O)W&#x2014;; W is a bond, &#x2014;NH&#x2014; or &#x2014;C(R)(R), wherein Rand Rare independently H, methyl, ethyl, amino, hydroxyl or halo; and Ris a radical as defined in the claims. 

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Slough, United Kingdom

John Montana