Kaleido Biosciences, Inc.

Flagship Pioneering Innovations V, Inc.

Children's Medical Center Corporation

Dsm Nutritional Products Inc.

Beth Israel Deaconess Medical Center, Inc.

Sana Biotechnology, Inc.

John Miles Milwid

Geoffrey Von Maltzahn

John M Geremia

Pedro J Del Nido

Jared Silverman

Yvonne J Yamanaka

Jacob Rosenblum Rubens

Michael Travis Mee

Kyle Marvin Trudeau

Kiana Mahdaviani

James D McCully

Douglas B Cowan

Neal Gordon

Jacob Feala

David Chess

Bo Zhang

Molly Krisann Gibson

Sidney Levitsky

Nathan Wilson Stebbins

Brigham Jay Hartley

Tamar Rose Putiri

Matthew Milnes Dobbin

Jagesh Vijaykumar Shah

Sitaram M Emani

Neal Francis Gordon

Geoffrey A Von Maltzahn

DouglasB Cowan

Michael Mee

The present disclosure provides, at least in part, methods and compositions for in vivo fusosome delivery. In some embodiments, the fusosome comprises a combination of elements that promote specificity for target cells, e.g., one or more of a fusogen, a positive target cell-specific regulatory element, and a non-target cell-specific regulatory element. In some embodiments, the fusosome comprises one or more modifications that decrease an immune response against the fusosome.

Fusosome compositions and uses thereof

Preparations of glycan therapeutics, pharmaceutical compositions, dietary supplements and medical foods thereof are provided, and methods of using said gycan therapeutics, e.g. in cancer therapy.

Glycan therapeutic compositions and related methods thereof

Therapeutic chondrisome and mitoplast compositions and related methods are described.

Methods and compositions relating to chondrisomes from blood products

Therapeutic chondrisome compositions and related methods are described.

Methods and compositions relating to chondrisomes from cultured cells

Preparations of glycan therapeutics, pharmaceutical compositions, dietary supplements and medical foods thereof are provided, and methods of using said glycan therapeutics, e.g. in cancer therapy.

In some aspects, fusosome compositions and methods are described herein that comprise membrane enclosed preparations, comprising a fusogen. In some embodiments, the fusosome can the target cell, thereby delivering complex biologic agents to the target cell cytoplasm.

Compositions for facilitating membrane fusion and uses thereof

Preparations of glycan therapeutics, pharmaceutical compositions and medical foods thereof, optionally comprising micronutrients, polyphenols, prebiotics, probiotics, or other agents are provided and methods of making same. Also provided are methods of using said gycan therapeutics, e.g. for the modulation of human gastrointestinal microbiota and to treat dysbioses.

Glycan therapeutics and method of treating conditions associated with TMAO

Glycan therapeutics and related methods thereof

Preparations of glycan therapeutics, pharmaceutical compositions and medical foods thereof, optionally comprising micronutrients, polyphenols, prebiotics, probiotics, or other agents are provided and methods of making same. Also provided are methods of using said glycan therapeutics, e.g. for the modulation of human gastrointestinal microbiota and to treat dysbioses.

Glycan therapeutics for reducing blood ammonia

Growing community of inventors

Winchester, MA, United States of America

John Miles Milwid