The Provost, Fellows, Foundation Scholars, and the Other Members of Board, of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin

John Michael Southern

Stephen Joseph Connon

Stephen J Connon

The present invention describes compounds of formula (I) Wherein:Ris selected from H and CHRis selected from H, CHalkyl, CHalkyl and CH-phenyl, said phenyl optionally substituted by OH or OCH, (1R,2S,5S)-5-methylcyclopent-3-ene-1,2-diolX is O or SY is C, N or S. These compounds have been identified as novel compounds useful in the treatment of multiple sclerosis and other autoimmune diseases.

Substituted pyrimidine derivatives useful in the treatment of autoimmune diseases

Disclosed are novel compounds useful in the treatment of multiple sclerosis and other autoimmune diseases. The present invention describes compounds of formula (I) wherein:Ris selected from H and CHRis selected from H, CHalkyl, CHalkyl and CH-phenyl, said phenyl optionally substituted by OH or OCH, (1R,2S,5S)-5-methylcyclopent-3-ene-1,2-diolX is O or SY is C, N or S.

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Dublin, Ireland

John Michael Southern