Smithkline Beecham Corporation

Replidyne, Inc.

Glaxo Group Limited

John Michael Berge

Richard Lewis Jarvest

Andrew Keith Forrest

Dieter Hamprecht

Lee James Beeley

Catherine Simone Victoire Frydrych

Mervyn Thompson

Jian Qiu

Robert William Ward

David Kenneth Dean

Robert John Sheppard

Joseph Guiles

Nikesh R Kotecha

John Stephen Elder

Theodore M Tarasow

Pamela Brown

David Jonathan McNair

Dieter Wolfgang Hamprecht

The present invention relates to compounds of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical microbial infections in a human or animal body.

Compounds

Compounds of formula (I): are inhibitors of bacterial methionyl tRNA synthetase and are of use in treating bacterial infections.

Compositions and methods for topical administration of 2-NH-heteroarylimidazoles

Novel substituted thiophenes that are inhibitors of bacterial methionyl t-RNA synthetase (MRS) are disclosed. Also disclosed are method for their preparation and their use in therapy as anti-bacterial agents.

Substituted thiophenes with antibacterial activity

Compounds of formula (I):are inhibitors of bacterial methionyl tRNA synthetase and are of use in treating bacterial infections.

2-NH-heteroarylimidazoles with antibacterial activity

Quinolones used as MRS inhibitors and bactericides

A compound of formula (I): ##STR1## or a pharmaceutically acceptable salt, or solvate thereof, wherein,

Derivatives of 4-(2-aminoethyl)phenoxymethyl-phosphonic and -phosphinic

##STR1## A compound of formula (I) or a pharmaceutically acceptable salt, ester or amide thereof, or a pharmaceutically acceptable solvate thereof, wherein R.sup.0 represents a substituted or unsubstituted aryl group; R.sup.1 represents hydrogen or an alkyl group; R.sup.2 represents a moiety of formula (a) wherein R.sup.4 and R.sup.5 each independently represent hydrogen, alkyl, hydroxyalkyl, cycloalkyl or R.sup.4 together with R.sup.5 represents (CH.sub.2).sub.n wherein n is 2, 3 or 4; T represents hydrogen, nitrile or a group --CO.R.sup.s wherein R.sup.s represents hydroxy, alkoxy or a group --NR.sup.t R.sup.u wherein R.sup.t and R.sup.u independently represent hydrogen, alkyl or R.sup.t and R.sup.u together with the nitrogen to which they are attached represent a saturated heterocyclic group; and R.sup.3 represents hydrogen, halogen, alkyl or alkoxy; a process for the preparation of such a compound, a pharmaceutical composition comprising such a compound and the use of such a compound in medicine.

Phosphonated arylethanolamine compounds with anti-hyperglycemic and/or

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Harlow, United Kingdom

John Michael Berge