Bend Research, Inc.

Capsugel Belgium Nv

John Michael Baumann

Dwayne Thomas Friesen

David D Newbold

Douglas Lee Millard

Devon Dubose

Devon B DuBose

James Mathew Mullin

Daniel Elmont Dobry

Brandon John Downey

Travis L Harrer

Anthony Quach

Dave Hansen

Douglas L Millard

Spray drying method and systems are disclosed that include one or more single-use components. Single-use spray drying systems can include a drying chamber with an inner surface formed of a polymeric material. The single-use components can be pre-sterilized and sterile packaged to provide improved efficiencies and greater operational flexibility in spray drying systems.

Single-use spray drying components and methods of using the same

Spray drying method and systems are disclosed that include one or more single-use components. Single-use spray drying systems can include a drying chamber with an inner surface formed of a polymeric material. The single-use components can be pre-sterilized and sterile packaged to provide improved efficiencies and greater flexibility in spray drying systems.

The process comprises delivering a spray solution comprising an active agent and a matrix material in an organic solvent to a spray-drying apparatus, atomizing the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the organic solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution may be formed by forming a feed suspension comprising the active agent, the matrix material, and the organic solvent, wherein the feed suspension is at a temperature T, and directing the feed suspension to a heat exchanger, thereby increasing the temperature of the feed suspension to a temperature T, wherein Tis greater than T, and the spray solution is at a pressure greater than the vapor pressure of the organic solvent at T, such that the active agent and matrix material are soluble in the organic solvent at T.

Spray-drying process

A spray-drying apparatus includes a drying chamber that has a first end, a second end, and at least one side wall extending between the first and second ends to define an interior of the drying chamber having a center axis. A nozzle can be positioned at the first end of the drying chamber and be configured to atomize liquid and spray the atomized liquid into the interior of the drying chamber at a maximum spray pattern angle relative to the center axis. A heating device can be provided to heat the liquid prior to introduction into the drying chamber.

Spray-drying apparatus and methods of using the same

The process comprises delivering a spray solution comprising at least one solute in a solvent to a spray-drying apparatus, using a flash nozzle to atomize the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution is directed to a heat exchanger, thereby increasing the temperature of the spray solution to a temperature T, wherein Tis greater than T. The flash nozzle comprises a central tube through which the spray solution is delivered and an outer tube through which a sweep gas is delivered. The central tube may have a first outer diameter at an inlet and a second outer diameter at an outlet, wherein the first outer diameter is greater than the second outer diameter.

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Bend, OR, United States of America

John Michael Baumann