Maelor Pharmaceuticals Limited

Isis Pharmaceuticals, Inc.

John Meadows

Mark Geoffrey Rippon

Colum Martin Dwyer

James David Du Mayne

Drugs which are difficult to solubilize in water, and especially those which otherwise cause pain on injection, can be readily formulated and typically administered with substantially less pain when solubilized in synergistic, aqueous micellar preparations of poloxamers. Such preparations may also be prepared with less, or without, co-solvents.

Synergistic mixed poloxamer systems for the solubilisation of drugs

Propofol solubilised in aqueous micellar preparations of poloxamers is stable at low concentrations and that such preparations are effective administration forms for Propofol.

Anesthetic formulations

The present invention relates to hydrogels, in particular gels for use on wounds. The invention provides a gel which is better able to maintain viscosity and gel integrity when exposed to wound exudates, for example. A hydrogel comprising a poloxamer is provided. Further provided is a hydrogel comprising a cross-linked gellant, and water wherein the hydrogel comprises a poloxamer and has the capacity to absorb at least 50% further water in addition to the water already present. Suitable gellants are pharmaceutically acceptable, cross-linked, hydrophilic polymers. Hydrogels of the present invention are useful in medicine, or therapy and are in particular useful in application to epithelial lesions, especially wounds, such as accidental or surgical wounds.

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Newbridge, United Kingdom

John Meadows