The Governors of the University of Alberta

The Secretary of State for Environment, Food and Rural Affairs

Other

John McGiven

Laurence Howells

David R Bundle

Susmita Sarkar

Satadru Sekhar Mandal

Julie Guiard

Lucy Duncombe

Vijaya Ganesh Narayanaswamy

David Bundle

There is provided a molecule comprising a chain of seven or more contiguous units of 4,6-dideoxy-4-acylamido-α-pyranose each pair of units joined by a C-Cor a C-Clink, the chain having a terminal end and a reducing end, wherein the pyranose ring in the unit of the chain most distal from the reducing end is linked to a cap structure. The cap structure is not a 4,6-dideoxy-4-acylamido-α-pyranose. There are also provided vaccine compositions comprising the molecule and methods of vaccinating an animal against infection by aorganism, including methods of distinguishing between a vaccinated and an infected animal. There are further provided novel methods of detecting the presence in a sample of an anti-antibody.

Polysaccharide and methods

There is provided a molecule comprising a chain of seven or more contiguous units of 4,6-dideoxy-4-acylamido-&#x3b1;-pyranose, each pair of units joined by a C-Cor a C-Clink, the chain having a terminal end and a reducing end, wherein the pyranose ring in the unit of the chain most distal from the reducing end is linked to a cap structure. The cap structure is not a 4,6-dideoxy-4-acylamido-&#x3b1;-pyranose. There are also provided vaccine compositions comprising the molecule and methods of vaccinating an animal NI against infection by aorganism, including methods of distinguishing between a vaccinated and an infected animal. There are further provided novel methods of detecting the presence in a sample of an anti-antibody.

There is provided a method of detecting in a sample the presence of an anti-M and/or anti-A and/or anti-C/Y antibody, the method comprising contacting the sample with a diagnostic conjugate provided according to the invention, comprising an oligosaccharide which comprises at least two units of 4,6-dideoxy-4-acylamido-&#x3b1;-pyranose and comprising at least one -(1-3)- link between adjacent 4,6-dideoxy-4-acylamido-&#x3b1;-pyranose units, in which the carbon at position 5 in the pyranose is linked to an R group, where R is independently selected from &#x2014;CHOH, &#x2014;H or an alkyl group having at least one C atom, the oligosaccharide being covalently linked to a non-saccharide molecule or to a surface.

Oligosaccharide conjugates and methods of use

There is provided a method of detecting in a sample the presence of an anti-M and/or anti-A and/or anti-C/Y antibody, the method comprising contacting the sample with a diagnostic conjugate provided according to the invention, comprising an oligosaccharide which comprises at least two units of 4,6-dideoxy-4-acylamido-&#x3b1;-pyranose and comprising at least one -(1-3)-link between adjacent 4,6-dideoxy-4-acylamido-&#x3b1;-pyranose units, in which the carbon at position 5 in the pyranose is linked to an R group, where R is independently selected from &#x2014;CHOH, &#x2014;H or an alkyl group having at least one C atom, the oligosaccharide being covalently linked to a non-saccharide molecule or to a surface.

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Surrey, United Kingdom

John McGiven