Stryker Corporation

John McCartney

Hermann Oppermann

Mei-Sheng Tai

The invention provides modified TGF-&#x3b2; family proteins having altered biological or biochemical properties, and methods for making them. Specific modified protein constructs include TGF-&#x3b2; family member proteins that have N-terminal truncations, 'latent' proteins, fusion proteins and heterodimers.

Modified TGF-&#x3b2; superfamily protein

The invention provides modified proteins and DNAs of the TGF-&#x3b2; superfamily including modified morphogenic proteins. The proteins of the present invention display altered biological or biochemical attributes. Specifically, the modified proteins are designed through manipulation or exchange of subdomains among two or more members of the superfamily such that certain desired attributes are mixed-and-matched and then exploited therapeutically.

Modified proteins of the TGF-&#x3b2; superfamily, including morphogenic proteins

The invention provides modified proteins and DNAs of the TGF-&bgr; superfamily including modified morphogenic proteins. The proteins of the present invention display altered biological or biochemical attributes. Specifically, the modified proteins are designed through substitutions of amino acids in the finger 2 sub-domain or exchanges of all or part of the finger 2 sub-domain of one TGF-&bgr; superfamily member with the finger 2 sub-domain of another TGF-&bgr; superfamily member.

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Holliston, MA, United States of America

John McCartney