Genetics Institute, Inc.

Wyeth

Bioventus, LLC

Other

Harvard College

Fidia Advanced Biopolymers S.r.l.

Genetics, Institute Institute, Llc.

New York Society for the Relief of the Ruptured and Crippled, Maintaining the Hospital for Special Surgery

Genetics Institute, LLC Et Al.

John Martin Wozney

Vicki A Rosen

Anthony J Celeste

Elizabeth A Wang

Howard Seeherman

Christopher Todd Brown

Douglas A Melton

Neil M Wolfman

Gerald H Thomsen

Eric Vanderploeg

R Scott Thies

Christopher Wilson

Robert Vincent Martinez

Valerie Calabro

Stephen Berasi

Michael John Cain

Zong Sean Juo

Noboru Yamaji

Lanfranco Callegaro

Rodney M Hewick

Alessandra Pavesio

Rebecca Li

Jack H Wang

Hyun Kim

John A Kambouris

Jeffrey R Song

Russell F Warren

Debra D Pittman

Randal J Kaufman

Scott Rodeo

Thomas J Turek

Jo A Hannafin

Scott R Thies

Alnawaz Rehemtulla

Jeffrey Welch

Cheryl Lee

Chase Davis

Z Sean Juo

Valerie Perrine Calabro

Christopher G Wilson

Christopher Brown

John Kambouris

Eric J Vanderploeg

Stephen Peter Berasi

Howard Joel Seeherman

Robert Vincent Paul Martinez

Valarie Perrine Calabro

Scott A Rodeo

Russel F Warren

Gerald H Thomson

Vicky A Rosen

Medical devices, substrates and biologic therapies for bone repair and guided tissue regeneration are disclosed. More particularly, bone graft substitutes and bone void fillers which comprise a porous collagen matrix and calcium deficient hydroxyapatite ceramic granules for delivery of osteoinductive or other therapeutic agents are disclosed.

Porous carrier matrix

Systems and methods for preparing synthetic osteoinductive bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.

Systems and methods for improved delivery of osteoinductive molecules in bone repair

The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.

Designer osteogenic proteins

Osteoconductive synthetic bone grafts are provided in which porous metallic matrices are loaded with an osteoinductive protein. In certain embodiments, the grafts include porous ceramic granules deposited within the matrices.

Protein delivery with porous metallic structure

Systems and methods for preparing osteoinductive synthetic bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.

Matrix for enhanced delivery of osteoinductive molecules in bone repair

Osteogenic proteins

An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising osteogenic protein, hyaluronic acid derivatives and tricalcium phosphate are also disclosed. Methods for formulating porous injectable gels and pastes from hyaluronic acid are also disclosed.

Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins

Purified cartilage and/or bone inductive proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.

Bone and cartilage inductive proteins

Compositions of proteins with tendon/ligament-like tissue inducing activity are disclosed. The compositions are useful in the treatment of tendinitis and tendon or ligament defects and in related tissue repair.

Tendon-inducing methods

Purified BMP-2 and BMP-4 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.

BMP products

Growing community of inventors

Hudson, MA, United States of America

John Martin Wozney