Cancer Research Technology Limited

University of London

University of Kent

John Marshall

Mark Howard

Danielle Dicara

Kerry Chester

Danielle DiCara

Ahuva Nissim

Heide Kogelberg

Margaret Brimble

The present disclosure provides a method for generating an affinity reagent library against a target protein which interacts with a ligand, which comprises the following steps; &#x2022;i) determining one or more structural element(s) of the ligand which are involved in ligand: target protein interaction; &#x2022;ii) producing a library of peptides which retain these structural element(s); and &#x2022;iii) grafting each peptide from the library of peptides into a portion of the affinity reagent molecule such that it may interact with the target protein, in order to produce an affinity reagent library.

Method for generating an affinity reagent library

AV&#x3b2;6 peptide ligands, functional variants thereof and their nucleic acids encoding them are disclosed with their uses in the treatment and imaging of AV&#x3b2;6 mediated diseases.

&#x3b1;v&#x3b2;6 peptide ligands and their uses

The present invention relates to antibodies that are obtained by inserting an amino acid sequence capable of binding to a target into the complementarity determining region (CDR) of a parent antibody. The antibody thus obtained has a new binding specificity. For example, the antibodies of the present invention are able to bind to the target, such as &#x3b1;v&#x3b2;6 integrin, while retaining one or more of the useful properties of the parent antibody.

Rationally-designed anti-&#x3b1;&#x3b2;&#x3bd;6 integrin antibody MFEVP1 and variants thereof, method of making such antibody and the use thereof in treating and diagnosis of disease

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London, United Kingdom

John Marshall