Boehringer Ingelheim International Gmbh

Zoetis Services LLC

John Mark Heimlich

Todd P Foster

Sumitra Rajagopalan

Derek James Sheehan

Nicholas Finn Cunningham

Joseph Peter Reo

Ernest J Lee

Jeffrey Ellis Price

Connie Jo Skoug

Gregory Everett Amidon

Christina Lee Brown

Alexandre Therrien

Loksidh Devi Ganorkar

Oscar Suarez

Robert Martin Noack

The present disclosure relates generally to sol-gel polymer composites that comprise chitosan, a hydrophilic polymer, a polysiloxane, and a gelation agent in a suitable medium. Advantageously, the sol-gel polymer composite can form a durable seal or strong solid in response to one or more physiological stimulus. The disclosure further relates to medical and veterinary uses of the composite, particularly, methods and delivery systems for reducing or preventing the incidence of a mammary disorder in a dairy animal. More particularly, the disclosure includes methods and sol-gel polymer composite compositions for creating a physical barrier on the teat surface or in the teat canal or cistern of a non-human animal for prophylactic treatment of mammary disorders such as mastitis wherein the sol-gel polymer creates a seal in response to one or more physiological stimulus.

Veterinary compositions for use in treating mastitis, and associated methods

A sustained-release pharmaceutical composition in a form of an orally deliverable tablet comprises a water-soluble salt of pramipexole, dispersed in a matrix comprising a hydrophilic polymer and a starch having a tensile strength of at least about 0.15 kN cmat a solid fraction representative of the tablet.

Sustained-release tablet composition of pramipexole

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Portage, MI, United States of America

John Mark Heimlich