Merck + Co., Inc.

Other

Genzyme Corporation

Merck Sharp + Dohme Corp.

John M Williams

Ulf H Dolling

Ronald B Jobson

Bradford Hirth

Robert B Williams

John L Kane, Jr

Scott F Sneddon

Shuang Qiao

Sharon R Nahill

Hans-Peter Biemann

Daniel Richard Sidler

Karel M J Brands

Raymond Cvetovich

Louis S Crocker

Fred Vinick

Michael D Ward

Ian Frank Cottrell

Michael J Kaufman

Michael Stewart Ashwood

Frederic Vinick

Mark Cameron

Karel M Brands

Amar J Mahajan

Elizabeth S Fisher

Andrew Janjigian

Antony J Davies

John L Kane

Bradford H Hirth

Renato Skerlj

Feng Xu

Renato T Skerlj

Michael Albert Winters

Chitrananda Abeygunawardana

Joseph S Amato

Luwy Kavuka Musey

Patrick McHugh

Robert Wenslow

Julie Marie Skinner

Joseph G Joyce

Jian He

Hsien-Hsin Tung

Emily Wen

William J Smith

William A Hunke

David C Dubost

Apurba Bhattacharya

John E MacNair

Brian K Johnson

Joseph Kukura, Ii

Karen M Conrad

Robert M Wenslow, Jr

Kimberly A Savary

Charles Orella

Peter Houghton

Karel J M Brands

Orn Almarsson

John D Stong

Albert L Galloup

Hari Pujar

Jeffrey A Zimmerman

Paul A Bergquist

Lisa M DiMichele

Catherine Lancaster

Robert M Wenslow

Daniel R Sidler

Ronald Jobson

Daniel Sidler

Joseph Ii Kukura

Louis Crocker

The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides frombacterial capsules are conjugated to a carrier protein in an aprotic solvent such as dimethylsulfoxide (DMSO). The present invention also provides methods for providing an enhanced immune response to a pneumococcal polysaccharide protein conjugate vaccine comprising administering to a human subject an immunogenic composition comprising polysaccharide-protein conjugates prepared in DMSO conditions.

Enhancing immunogenicity ofpolysaccharide-protein conjugates

Elongated mounting strips are provided with a series of evenly spaced apart tile fasteners. The tile fasteners pivot from a storage or shipping position to an installation position where they engage and secure the top edges of cladding tile. Strips of weather resistant material are also mounted to the mounting strips at evenly spaced intervals. The weather resistant strips also pivot from a storage or shipping position to an installation position underlying a joint between a pair of adjacent cladding tiles.

Building cladding installation system

A slate and tile roofing system includes a base layer of compliant roofing material and a series of tile fasteners fixed along a top portion of the roofing material. A series of weather barrier strips is attached to the series of fasteners and fixed to the roofing material. A series of slate tiles is semi-permanently mounted over the weather barriers to form a prefabricated tile roofing subassembly. The subassembly expedites and facilitates the installation of slate and tile roofs without the need for highly specialized labor.

Prefabricated slate and tile roofing

The present invention provides compounds which are modulators of TNF-&#x3b1; signaling and methods of use thereof for treating a patient having a TNF-&#x3b1; mediated condition. The compounds can be represented by the following structural formulas: 

Modulators of TNF-&#x3b1; signaling

A cantilevered leaf spring is biased against the upper edge of a roofing tile to prevent the tile from sliding upward beneath an overlying upper row of roofing tiles. The leaf spring can be formed as a part of a tile fastener which includes a hooked portion for receiving and holding the lower edge of a roofing tile on a roof. A series of tile fasteners is mounted to a layer of roofing material to facilitate installation of tiles without the need for installation tools. Damaged tiles can be easily replaced without the need for installation or removal tools. With this system, each row of underlying tiles is locked in place by the combined effect of an overlying and overlapping row of tiles and a spring awl on an upper fastener pushing the upper edge of a tile downwardly so that the lower edge of the tile is forced into the mouth of a lower fastener.

Roofing tile fastener and locking system

Lightweight tile roofs using a single overlap of tiles between adjacent tile courses are protected from wind, rain, snow, ice, humidity and sun with a base layer of water resistant weatherproofing material and with a series of waterproof or water resistant shield strips. The shield strips are laterally spaced apart so as to underlie the cracks, joints or channels formed between the adjacent side edges of each pair of juxtaposed tiles. This double layer of weatherproofing material extends the useful life of lightweight tile roofs.

Weather shielding system for slate and tile roofs

A roofing tile installation system includes spaced rows of installation strips each having an elongated base to which is attached a plurality of spaced apart hooks. The hooks are formed with a profile that engages and presses on underlying tiles and that grips and hooks around the lower edge of an overlying tile. Each tile is positioned and held laterally between a pair of hooks and held vertically on the slope of a roof by a single hook. An improved weatherproofing system includes a second layer of water resistive material which protects an underlying layer of plastic weatherproofing material against exposure to sunlight and erosion from wind and rain.

Roofing tile fastening system

An integral roof and gable edge assembly includes a metal or plastic sheet formed with positioning surfaces to facilitate slate tile installation by relatively unskilled roofers. The roof and gable assemblies include one or more hooks for holding one or more slate, ceramic or other similar roofing tiles in fixed position along the eaves and/or gables of a roof. A lift arm can be provided on the roof assemblies to replace cant strips and simplify tile installation. Tiles can be easily installed without nailing through the tiles.

Edge assemblies for slate and tile roofs

An integral strip and fastener installation system is provided for light weight slate and tile roofing systems installed with a single overlap between each row or course of tile. A specialized fastener hook is formed with one or more lateral projections or wings installed underneath one or more slate tiles to anchor the fastener to the roof at least in part by the weight of the overlying tiles. This anchoring supports and reinforces the open mouth of the hook against deflection from high winds and thereby enables the hook to hold a tile securely under high wind loads.

Wind resistant tile roofing system

Modulators of TNF-&#x3b1;signaling

A double sided polypropylene knit loop fabric comprises at least one and preferably both of the inner and outer loops comprised of polypropylene yarn forming cantilevered loops from a knit fabric. Polypropylene has many different characteristics than those of cotton or cotton blends. Accordingly, by making at least one of the loops, if not both of the loops, and the tie yarn out at least substantially, if not principally, polypropylene, a fabric can be produced which has different characteristics than a cotton fabric of similar construction.

Double sided polypropylene knit loop fabric

Disclosed is a method of inhibiting acute and chronic tissue transplant rejection in a subject with a tissue transplant. The method comprises the step of administering to the subject an effective amount of a compound represented by Formula (I): The values of the variables in Formula (I) are described herein.

Inhibition of chronic tissue transplant rejection

Methods of inducing immune tolerance by administering an immunosuppressive agent and a compound represented by Formula (I) are disclosed:  Additionally methods of suppressing an immune response by administering an immunosuppressive agent and a compound represented by Formula (I) are disclosed. Further disclosed are methods for treating autoimmune diseases by administering an immunosuppressive agent and a compound represented by Formula (I). The variables of Formula (I) are described herein.

Induction of immune tolerance

A process for preparing a crystalline, carbapenem monosodium salt of formula IIa:characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than &#x2212;5&#xb0; C., c) adjusting the pH using a solution containing an acid in an organic solvent to give the appropriate pH for crystallization, and d) crystallizing the compound by adding methanol, and a Calcohol at between &#x2212;5 and &#x2212;25&#xb0; C.

Crystalline forms of carbapenem antibiotics and methods of preparation

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Wells, VT, United States of America

John M Williams