Beckman Coulter, Inc.

Tech Medical Devices Inc.

John M Wallach

Xihai Mu

An ion selective electrode ('ISE') assembly may be installed within a sample path of a biological testing system to measure ion concentration within sample fluid flowing through the sample path. A transducer membrane is placed within a housing and positioned to contact the sample path. A threaded portion is advanced into a socket of the housing and forces the membrane against a sealing portion of the sample path to prevent retention of sample fluid within the housing after testing. Sealing may be accomplished without adhesives or sealants and instead relies upon mechanical pressure of the threaded portion. Another implementation includes a reference measuring electrode and several ion measuring electrodes combined into a single housing. Another implementation includes a reference measuring electrode and several ion measuring electrodes combined into a cartridge that includes a sample well instead of a sample path.

Solid state ion selective electrodes

An ion selective electrode ('ISE') assembly may be installed within a sample path of a biological testing system to measure ion concentration within sample fluid flowing through the sample path. A transducer membrane is placed within a housing and positioned to contact the sample path. A threaded portion is advanced into a socket of the housing and forces the membrane against a sealing portion of the sample path to prevent retention of sample fluid within the housing after testing. Sealing may be accomplished without adhesives or sealants and instead relies upon mechanical pressure of the threaded portion.

A system, method and apparatus for temperature regulation of physiological fluids is disclosed. In an exemplary system for use in cardiopulmonary procedures, blood is entered into a proportionally long, narrow disposable container, is heated or cooled to a desired temperature, and exits from an opposite end. The disposable container includes a pair of long, flat surfaces facing each other in relatively, close proximity. The blood is transitioned from transport tubing into a thin laminar flow layer and back into tubing, inside the container. This container is placed in a heat exchange device having thermoelectric modules that contact the majority of surface area, opposite the blood side in the container. The thermoelectric modules act as fully reversible heat pumps and move heat from one side of the module to the other, dependant on the direction of the current supplied to the modules. Feedback from sensors in the fluid path independently control each thermoelectric module.

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Diamond Bar, CA, United States of America

John M Wallach