Qiagen North American Holdings, Inc

Gentra Systems, Inc.

Cts Biopharma LLC

John M Wages

Ellen M Heath

Kim Paulsen

Robert Jackson Bair

Heather Meehan

James W Larrick

Bo Yu

Robert W Kwiatkowski, Jr

Robert W Kwiatkowski

Kristen Campbell Benedict

Andrew Mendelsohn

Wendy J Kivens

Vikram Sharma

Daniel A Strom

Kim E Paulsen

Wendy J Kivins

The present disclosure provides chimeric, humanized and human monoclonal antibodies (mAbs) and fragments thereof that specifically bind to marinobufagenin (MBG) with high affinity. The anti-MBG mAbs and fragments thereof can be used to treat MBG-associated disorders, including hypertensive disorders and fibrotic disorders, optionally in combination with an additional therapeutic agent. Furthermore, the anti-MBG mAbs and fragments thereof can be used for diagnostic purposes, including to detect MBG in biological samples and to diagnose MBG-associated disorders.

Anti-marinobufagenin antibodies and uses thereof

The present disclosure provides methods for isolating substantially pure and undegraded DNA from biological material via a solid support. The methods may use a DNA lysing solution that comprises a surfactant, a DNA-complexing salt (e.g., a lithium salt), and a buffer. Alternatively, the methods may use a solid support pre-treated with the DNA lysing solution.

Compositions and methods for using a solid support to purify DNA

Reagents, methods and kits for the purification of RNA from biological materials are provided.

Compositions and methods for using a solid support to purify RNA

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Tupelo, MS, United States of America

John M Wages