Corixa Corporation

John M Smith

Steven G Reed

Tony Nick Frudakis

Yasir A W Skeiky

Lynda Misher

Davin C Dillon

Marc W Retter

Michael J Lodes

Patricia Dianne McNeill

Raymond L Houghton

Susan L Harlocker

Aijun Wang

Samuel X Li

Craig H Day

Ta Deng

Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.

Compositions and methods for the therapy and diagnosis of breast cancer

Compositions and methods for the detection and therapy of breast cancer are disclosed. The compounds provided include nucleotide sequences that are preferentially expressed in breast tumor tissue, as well as polypeptides encoded by such nucleotide sequences. Vaccines and pharmaceutical compositions comprising such compounds are also provided and may be used, for example, for the prevention and treatment of breast cancer. The polypeptides may also be used for the production of antibodies, which are useful for diagnosing and monitoring the progression of breast cancer in a patient.

Compositions and methods for the treatment and diagnosis of breast cancer

Compounds and methods are provided for diagnosing infection. The disclosed compounds are polypeptides, or antibodies thereto, that contain one or more epitopes of antigens. The compounds are useful in a variety of immunoassays for detecting infection. The polypeptide compounds are further useful in vaccines and pharmaceutical compositions for inducing protective immunity against Chagas' disease in individuals exposed to

Compounds and methods for the detection and prevention of T.cruzi infection

Compounds and methods are provided for diagnosing,infection. The disclosed compounds are polypeptides, or antibodies thereto, that contain one or more epitopes of,antigens. The compounds are useful in a variety of immunoassays for detecting,infection. The polypeptide compounds are further useful in vaccines and pharmaceutical compositions for inducing protective immunity against Chagas' disease in individuals exposed to

Compounds and methods for the detection and prevention of T. cruzi infection

Growing community of inventors

Everett, WA, United States of America

John M Smith