Other

Rolls-Royce Corporation

John M Robertson

Raymond A Dwek

Nicole Zitzmann

James P Angus

Jack Palfreyman

Pauline Rudd

Catherine M Radcliffe

Louise Royle

Rosa Peracaula

Umi Marshida Abd Hamid

Rafael De Llorens

One can identify and quantify one or more glycosylation markers of cancer by utilizing quantitative HPLC analysis of glycans which have been released from unpurified glycoproteins. The unpurified glycoproteins can be total glycoproteins or a selection of the total glycoproteins. The identified glycosylation marker can be a native glycan or a digestion product which has been segregated and amplified by exoglycosidase digestions. One can utilize the identified glycosylation marker, for example, for diagnosing and/or monitoring cancer in a subject. One can also use the glycosylation marker to identify glycoprotein biomarkers that carry the glycosylation marker. Such biomarkers can also be used for monitoring and/or diagnosing cancer. The biomarker may also be a subset of glycoforms of a glycoprotein that are separated in trains of spots on 2D gel.

Glycosylation markers for cancer diagnosing and monitoring

A game for grabbing a playing marker before an opponent does to score a point. The game includes a playing mat with a pair of end edges and a pair of side edges. The playing mat also has a center point and a pair of base lines extending between the side edges of the playing mat. The center point is interposed between the base lines. Each of the base lines defines a base region extending from the respective base line and an adjacent associated end edge of the playing mat resting the playing mat. A marker piece is positioned on the center point of the playing mat. A first player places a hand on the playing mat in a first of the base regions and a second player places a hand on the playing mat in a second of the base regions. After a start command is issued the first and second players grab for the marker piece with the player grabbing the marker piece scoring a point.

Grabbing reflex game

A seal arrangement suitable for sealing between two coaxially mounted, axially restrained, radially spaced apart and relatively rotatable members comprises two concentric, ring-shaped seal elements having adjacent sealing faces. The seal elements are mounted on the respective members by a spline and groove arrangement which permits radial growth or shrinkage of the relatively rotatable members due to their thermal expansion or contraction without such growth or shrinkage being transferred to the seal elements. The arrangement insures that the gap between the sealing faces of the seal elements remains substantially constant during thermal variations.

Dual-ring seal with temperature compensation

A rotor support structure for a gas turbine engine comprises a rolling element bearing adapted to carry the rotor, a structurally strong ring adapted to carry the rolling element bearing, and two pairs of supporting struts for the ring, extending substantially tangentially from the ring, each pair joining at a mounting, the two mountings being diametrically opposed with respect to the ring.

Rotor support structure for a gas turbine engine

Growing community of inventors

Derby, United Kingdom

John M Robertson