Abbott Laboratories Corporation

John M Lindberg

Gary M Oosta

Joseph Larry Pezzaniti

Michael L McGlashen

Tayy-Wen Jeng

Hugh Alexander MacKenzie

Omar S Khalil

Tzyy-Wen Jeng

Charles F Hanna

Gerald G Vurek

Shu-jen Yeh

Robert A Gutcheck

Arnold F Stalder

Ete Z Szuts

J Larry Pezzaniti

Robert Eric Heinz

A system for measuring a biological parameter, such as blood glucose, the system comprising the steps of directing laser pulses from a light guide into a body part consisting of soft tissue, such as the tip of a finger to produce a photoacoustic interaction. The resulting acoustic signal is detected by a transducer and analyzed to provide the desired parameter.

System for measuring a biological parameter by means of photoacoustic interaction

Multiplex sensor and method of use

A multiplex sensor and a method of use that provides enhanced selectivity and sensitivity. In this method, one or more parameters of the sample are measured by means of multiple spectroscopic techniques, and the interferences from physiological and spectral variables are reduced or eliminated. In one embodiment of the present invention comprises a multiplex sensor and a method of use that provides enhanced selectivity and sensitivity. One or more parameters of the sample are measured by means of at least two different spectroscopic techniques, wherein the at least two different spectroscopic techniques are selected from the group consisting of:

A method and apparatus for measuring the concentration of an analyte of interest, e.g. glucose, in blood non-invasively, i.e., without penetrating the skin or obtaining a biological sample from the body of a patient. The method and apparatus uses a plurality of measurement channels with appropriate wavelengths of interest to control variations of signal and to separate the contribution of the analyte of interest from those of interfering compounds. The method and apparatus of this invention can also be adapted to allow a portion of a body part to be engorged with blood to bring about greater accuracy in optical measurements. In the method of this invention, at least two similar, but not identical, measurements are made concurrently. For example, at least two measurements can be made with similar, but not identical, wavelengths of electromagnetic radiation. The two wavelengths should not be overlapping to allow maximum non-identity. By making measurements concurrently, each measurement channel in the system experiences variations as they occur substantially simultaneously in all channels. By selecting one of the channels as a reference channel and by normalizing the optical measurements of the other channels to this reference channel, the variations common to all channels are eliminated. Removing these common variations from the optical measurements by normalization, such as by calculating ratios of the measurement of each of the measuring channels to that of the reference channel, will allow the actual changes of the signal for a specific analyte of interest to be measured.

Method and apparatus for non-invasively measuring the amount of glucose

A noninvasive Raman sensor and an associated method of measuring at least one parameter of a sample, such as the presence or concentration of an analyte. The sensor includes

Sensor utilizing Raman spectroscopy for non-invasive monitoring of

An apparatus and a process of determining the concentration of an optically active compound in a biological sample are provided. The process measures the entire polarization state of the sample and compares the measured polarization state of the sample to the polarization state of a sample having a known concentration of that compound. The polarization state of the sample is measured after manipulating the polarization state of light entering and leaving the sample and detecting the light leaving the sample. The apparatus contains a source of light, a sample holder for holding the biological sample, a detector, a first polarization manipulator between the light source and the sample holder, a second polarization manipulator between the sample holder and the detector and an analyzer to correlate detected signals with concentration of the optically active compound.

Apparatus and process for the non-invasive measurement of optically

The present invention provides a programmable filter for use as a standard in correlation spectrometers. Also provided is the use of the programmable standard in a process for determining the concentration of an optically absorbing compound. Also provided is a method and apparatus for noninvasively determining the concentration of an optically absorbing biological sample which incorporates the programmable standard of the invention.

Programmable standard for use in an apparatus and process for the

An optical distribution system incorporating an improved luminescent based optical fiber sensor incorporating a signal generating component for generating a first optical signal, a signal separating component for delivering said first optical signal to the sensor, delivering said second returned optical signal to an associated signal detector, and including signal interference means to separate said first and second signals and minimize cross-talk therebetween. A sensor optical fiber connects a sensor tip to the signal separating component. The signal detector receives a returned signal from the signal separating component and transmits it to a signal-measuring component of the distribution system.

Growing community of inventors

Grayslake, IL, United States of America

John M Lindberg