Kaleido Biosciences, Inc.

Dsm Nutritional Products Inc.

Dsm IP Assets B.v.

Cadena Bio, Inc.

Midori Usa, Inc.

Midori Renewables, Inc.

Hercules Capital, Inc.

John M Geremia

Geoffrey Von Maltzahn

Jared Silverman

John Miles Milwid

Yvonne J Yamanaka

Ashish Dhawan

Brian M Baynes

Lisa Ann Laprade

Jacob Rosenblum Rubens

Stephane Duval

Christopher Matthew Liu

Anastasia V Murphy

Estefania Perez Calvo

Viviane Verlhac

Ghislain Schyns

Scott S Han

Kyle Sherry

Benjamin A Seigal

Michael J Gidding

Alicia Landry

Joshua Thomas Claypool

Stephen Panos

Devin Churchman

Andrew O'Connor

Anastasia Lioubomirov

Anastasia V Lioubomirov

April Waguespack-Levy

Ulrich Hoeller

Raffi Mardirosian

Estel Canet-Martinez

Ruediger Hainz

Manuela Baur

Jonathan Lawrence

Max Hecht

Madeline Hartman

Britta Blokker

Tatyana Yatsunenko

Nathalie Richard

Jerome Schmeisser

Brian Meehan

Nicole Seifert

Jack Milwid

Joseph Andoh

Mitchell Antalek

Geoffrey A Von Maltzahn

Andrew O'connor

Ian Tamburini

Maxwell B Hecht

Mitchell Tyler Antalek

Rudiger Hainz

Ulrich HÖLLER

Estefania Perez-Calvo

Stéphane Duval

Aspects of the disclosure relate to oligosaccharide compositions and methods of making the same. Also provided are methods of using oligosaccharide compositions as microbiome metabolic therapies for reducing ammonia levels and for the treatment of hyperammonemia-related diseases (e.g., urea cycle disorders and hepatic encephalopathy).

Oligosaccharide compositions and methods of use thereof for reducing ammonia levels

Methods of feeding animals are disclosed wherein providing feed additives are provided that modulate the gut microbiome to improve the health, nutrition, and growth performance. Methods of modulating the microbial species present in the gastrointestinal tract of an animal are also disclosed. Such modulation includes, for example, modulating the level or function of microbial species.

Methods of selectively modulating gastrointestinal microbial growth

Preparations of glycan therapeutics, pharmaceutical compositions, dietary supplements and medical foods thereof are provided, and methods of using said gycan therapeutics, e.g. in cancer therapy.

Glycan therapeutic compositions and related methods thereof

The present disclosure relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to improve the health, nutrition, and growth performance. The present disclosure further relates to methods of modulating metabolites present in the gastrointestinal tract of an animal. Such modulation includes, for example, modulating the level said metabolites.

Methods of modulating gastrointestinal metabolites

The present disclosure relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to prevent or treat dysfunctions in a gastrointestinal barrier. The present disclosure further relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to prevent or treat infections.

Methods of supporting gastrointestinal homeostasis

The present disclosure relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to improve the health, nutrition, and growth performance. The present disclosure further relates to methods of modulating the microbial species present in the gastrointestinal tract of an animal. Such modulation includes, for example, modulating the level or function of microbial species.

Preparations of glycan therapeutics, pharmaceutical compositions, dietary supplements and medical foods thereof are provided, and methods of using said glycan therapeutics, e.g. in cancer therapy.

Preparations of glycan polymers and variations thereof, pharmaceutical compositions, medical foods, supplements, foods, food ingredients, feed ingredients, and feed additives thereof, optionally comprising micronutrients, polyphenols, prebiotics, probiotics, or other agents are provided and methods of making same.

Methods of producing glycan polymers

Described herein are methods of producing animal feed made up of oligosaccharide compositions, as well as methods of producing such oligosaccharide compositions and animal feed compositions, and methods of using such animal feed compositions to enhance animal growth.

Oligosaccharide compositions for use as animal feed and methods of producing thereof

The present disclosure relates oligosaccharide preparations suitable for use in nutritional compositions such as animal feed and methods of manufacturing the described oligosaccharide preparations. The present disclosure further relates to nutritional compositions that comprise the oligosaccharide preparations. The disclosed oligosaccharide preparations can be advantageous as an animal feed due to, at least in part, their prebiotic utility and the presence of anhydro-subunit containing oligosaccharides, which can be used to detect and/or determine the presence and content of the disclosed oligosaccharide preparations in the nutritional composition.

Oligosaccharide preparations and compositions

Described herein are methods for the production of oligosaccharides, including functionalized oligosaccharides, from one or more sugars, such as one or more monosaccharides, using polymeric and solid-supported catalysts containing acidic and ionic groups. Also provided are the oligosaccharide compositions, including functionalized oligosaccharide compositions, obtained using the methods.

Oligosaccharide compositions and methods for producing thereof

Preparations of glycan therapeutics, pharmaceutical compositions and medical foods thereof, optionally comprising micronutrients, polyphenols, prebiotics, probiotics, or other agents are provided and methods of making same. Also provided are methods of using said gycan therapeutics, e.g. for the modulation of human gastrointestinal microbiota and to treat dysbioses.

Glycan therapeutics and method of treating conditions associated with TMAO

Aspects of the disclosure relate to oligosaccharide compositions and methods of making the same. Also provided are methods of using oligosaccharide compositions as microbiome metabolic therapies for reducing ammonia levels and for the treatment of related diseases.

Oligosaccharide compositions and methods of use thereof

Glycan therapeutics and related methods thereof

Growing community of inventors

Watertown, MA, United States of America

John M Geremia