Pharmagenesis, Inc.

Ecopharm Corporation

Phytohealth Corporation

John M Fidler

John H Musser

Jinhua An

Ke Li

You Mao Qi

The teachings provided herein generally relate to the preparation and uses of compositions comprising extracts of. The extracts are prepared fromand can comprise, for example, an acid-modified arabinogalactan protein composition having an arabinose:galactose ratio ranging from about 3.5:1 to about 5.0:1, from about 5% to about 10% rhamnose, from about 15% to about 20% galactose, and from about 10% to about 15% glucose. The compositions can be used in the treatment of idiopathic thrombocytopenic purpura and the formulation of medicaments for such treatments.

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The identification of triptolide target molecules is described. Also described are methods of screening triptolide-related compounds for binding to these molecules, including screening for enhanced and/or selective binding, and expression analysis of the target molecules in normal and in diseased tissue.

Identification and screening of triptolide target molecules

Water soluble triptolide prodrugs are used as anticancer agents, and are found to be more effective in vivo, at lower doses, in reducing tumor size than the widely used chemotherapeutic agents 5-fluorouracil and irinotecan.

Anticancer treatment using triptolide prodrugs

Amino acid derivatives of triptolide compounds as immune modulators and anticancer agents

Immunosuppressive compounds and methods

Growing community of inventors

Oakland, CA, United States of America

John M Fidler