Affibody Ab

Amylonix Ab

John Löfblom

Elin Gunneriusson

Stefan Ståhl

Fredrik Frejd

Malin Lindborg

Caroline Ekblad

Torbjörn Gräslund

Johan Seijsing

Lars B Abrahmsen

Lars Abrahmsén

Torleif Härd

Lindvi Gudmundsdotter

Nina Kronqvist

Magdalena Malm

Hanna Lindberg

Lars ABRAHMSÉN

The present disclosure relates to a class of engineered polypeptides having a binding affinity for amyloid &#x3b2; (A&#x3b2;) peptides (in the following referred to as A&#x3b2;), comprising the amino acid sequence EXXYXXNLXA XQLCAXIXXXED (SEQ ID NO:632). The present disclosure also relates to the use of such A&#x3b2; peptide binding polypeptides as therapeutic, prognostic and/or diagnostic agents.

Alzheimer A&#x3b2; peptide binding polypeptide

The present disclosure relates to a class of engineered polypeptides having a binding affinity for the neonatal Fc receptor (in the following referred to as FcRn), and provides an FcRn binding polypeptide comprising the sequence EXXXAXXEIRWLPNL XXXQRXAFIXXLXX. The present disclosure also relates to the use of such an FcRn binding polypeptide as an agent for modifying pharmacokinetic and pharmacodynamic properties and as a therapeutic agent.

Polypeptides

The present disclosure relates to dimers of engineered polypeptides having a binding affinity for the neonatal Fc receptor FcRn, and provides an FcRn binding dimer, comprising a first monomer unit, a second monomer unit and an amino acid linker, wherein the first and second monomer units each comprises an FcRn binding motif. The FcRn binding dimer binds FcRn with higher capacity compared to the first monomer unit or second monomer unit alone. The present disclosure also relates to the use of the FcRn binding dimer as an agent for modifying pharmacokinetic and pharmacodynamic properties and as a therapeutic agent.

Neonatal Fc receptor binding dimer and methods of use

The disclosure provides a HER3 binding polypeptide, comprising a HER3 binding motif, BM, which motif consists of the amino acid sequence selected from i) EXXXA XXEIW XLPNL XXXQXXAFIXXLXD, and ii) an amino acid sequence which has at least 90% identity to the sequence defined in i), wherein the polypeptide binds to the extra-cellular domain of HER3. Also provided is a bispecific ligand having binding affinity for HER3 and for HER2, or for HER3 and for EGFR, and comprising a HER3. binding polypeptide as defined herein and a HER2 binding polypeptide or a EGFR binding polypeptide.

HER3 binding polypeptides

The present disclosure relates to polypeptides which bind to human epidermal growth factor receptor 3 (HER3) and to use of such polypeptides in imaging and therapy. The disclosure provides an HER3 binding polypeptide comprising a HER3 binding motif, which motif consists of the amino acid sequence EKYXAYXEIW XLPNLTXXQXAAFIGXLXD (SEQ ID NO:110).

Growing community of inventors

Huddinge, Sweden

John Löfblom