Wyeth

Zealand Pharma A/s

John Leo Considine

Warren Chew

Silvio Iera

Jianxin Ren

Scott Mason Duncan

Sylvain Daigneault

Panolil C Raveendranath

Lalitha Krishnan

Mahmoud Mirmehrabi

Subodh S Deshmukh

Zhixian Ding

Maotang X Zhou

Karen Sutherland

Asaf Ragim Alimardanov

Charles Chao Wu

Jason Brazzillo

Ting-Zhong Wang

Galina Vid

John Potoski

Weiguo Liu

Jiaxin Ren

Jiaxen Ren

Karen Wiggins Sutherland

Charles C Wu

Provided are methods for the preparation of certain substituted pyrrolidine compounds, forms of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride, and methods for preparing and using these forms.

Synthesis of pyrrolidine compounds

This invention provides the use of a combination of CCI-779 and EKB-569 in the treatment of neoplasms.

Antineoplastic combinations

The present invention concerns processes for the production and purification of compounds of the formula: where R-Rare as defined in the specification. Preferred processes of the invention utilize a lithium bis(trimethylsilyl)amide, lithium dicyclohexylamide, or potassium bis(trimethylsilyl)amide base and a R&#x2014;X alkylating agent where X is as described in the specification. An alcohol preferably is added to the product solution is used to promote crystallization of the desired product.

Preparation and purification of 4-(indazol-3-yl)phenols

The present invention provides processes for the preparation of compounds of Formula I, which are useful in the preparation of pharmaceuticals for the treatment of inflammatory diseases. The compounds of Formula I are also useful as pharmaceuticals. 

Processes for the preparation of 2-cyano-3-naphthalene-1-yl-3-phenyl-propionic acid alkyl or benzyl esters

This invention provides a compound of Formula (I): wherein

Synthesis of 4-(amino)-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines

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Bridgewater, NJ, United States of America

John Leo Considine