Virginia Tech Intellectual Properties Inc.

Texas Instruments Corporation

Virginia Polytechnic Institute and State University

John Lawrence Caldwell

Rafael V Davalos

Michael B Sano

Hadi Shafiee

Christopher B Arena

Steven Graham Brantley

Bharath Karthik Vasan

Devices and methods for performing dielectrophoresis are described. The devices contain sample channel which is separated by physical barriers from electrode channels which receive electrodes. The devices and methods may be used for the separation and analysis of particles in solution, including the separation and isolation of cells of a specific type. As the electrodes do not make contact with the sample, electrode fouling is avoided and sample integrity is better maintained.

Devices and methods for contactless dielectrophoresis for cell or particle manipulation

At least some embodiments are directed to a system comprising an amplifier containing a first bias current source and configured to provide an output voltage at a node, a gain stage coupled to the node and comprising a second bias current source, and a buffer stage coupled to the node and comprising third and fourth bias current sources and an additional set of bias current sources, the third and fourth bias current sources are able to activate output transistors that are configured to increase current provided to a load. The system also comprises a controller configured to activate the first bias current source, to activate the second bias current source after the first bias current source is activated, to activate the bias current sources in the set after the first bias current source is activated, and to activate the third and fourth bias current sources after the first and second bias current sources are activated and after the bias current sources in the set are activated.

Mitigating amplifier pop noise

The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. The invention can be used to treat solid tumors, such as brain tumors. The methods rely on non-thermal irreversible electroporation (IRE) or supra-poration to cause cell death in treated tumors. In embodiments, the methods comprise the integration of ultra-short electric pulses, both temporally and spatially, to achieve the desired modality of cell death.

Integration of very short electric pulses for minimally to noninvasive electroporation

Growing community of inventors

Tucson, AZ, United States of America

John Lawrence Caldwell