Merck Sharp + Dohme Corp.

Fred Hutchinson Cancer Center

The Netherlands Cancer Institute

John Lamb

Stephen H Friend

Roland Stoughton

Yudong He

Julian Simon

Laura Johanna Van't Veer

Eric E Schadt

Hongyue Dai

Heather Dunstan

A method for confirming the association of a query QTL or a query gene in the genome of a second species with a clinical trait T exhibited by the second species. A first QTL or a first gene in a first species that is linked to a trait T' is found. The trait T&#x2032; is indicative of trait T. A region of the genome of the first species that comprises the first QTL or the first gene is mapped to a particular region of the genome of the second species. A query QTL or a query gene in the second species that is potentially associated with the trait T is found. The potential association of the query QTL or the query gene with the clinical trait T is confirmed when the query QTL or the query gene is in the particular region of the genome of the second species.

Computer systems and methods for associating genes with traits using cross species data

The present invention provides prognostic methods for conditions such as cancer, for example, breast cancer, comprising classifying an individual by a plurality of phenotypic, genotypic or clinical characteristics of the condition into a plurality of patient subsets, and analyzing the pattern of expression of prognosis-informative genes identified for that subset in a sample from the individual. The present invention also provides methods for constructing such patient subsets and of identifying prognosis-informative genesets for such subsets. The invention further provides methods of assigning a therapeutic regimen to an individual, microarrays useful for performing prognosis, kits comprising these microarrays, and computer systems and programs for implementing the methods of the invention.

Classification of breast cancer patients using a combination of clinical criteria and informative genesets

Methods for the treatment of a proliferative disorder are provided in which a subject in need of such treatment is administered an effective amount of a compound selected from: compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein Xand Xare independently H, Cl, F, Br, I, CN, CFor NO, and Aris a substituted or unsubstituted aryl or a substituted or unsubstituted heteroaryl; and compounds of formula (II) wherein Xand Xare each independently H, Cl, F, Br, I, CN, CFor NO; Y is (C&#x2013;C)alkylene or (C&#x2013;C)heteroalkylene; and Z is Cl, F, Br, I, CN, CFor NO.

Topoisomerase poisons for the treatment of proliferative disorders

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Shoreline, WA, United States of America

John Lamb