Antibe Therapeutics Inc.

Other

Antibe Holdings Inc.

John L Wallace

Giuseppe Cirino

Giuseppe Caliendo

Vincenzo Santagada

Anna Sparatore

Stefano Fiorucci

Jonathan B Meddings

Lloyd Sutherland

Vicenzo Santagada

The present invention relates to derivatives of non-steroidal anti-inflammatory drugs (NSAIDs) having improved anti-inflammatory properties useful in the treatment of inflammation, pain and fever. More particularly, NSAIDs are derivatized with a hydrogen sulfide (HS) releasing moiety to produce novel anti-inflammatory compounds having reduced side effects.

Hydrogen sulfide derivatives of non-steroidal anti-inflammatory drugs

Derivatives of drugs are provided, said derivatives comprising the H2S-releasing moiety 4-hydroxythiobenzamide that is either covalently linked to the drug or forms a salt with the drug. The compounds of the present invention exhibit enhanced activity or reduced side effects or both.

4-hydroxythiobenzamide derivatives of drugs

The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.

Derivatives of 4- or 5-aminosalicylic acid

Unique salts of trimebutine and N-monodesmethyl trimebutine, and their corresponding stereoisomers, having improved analgesic properties useful in the treatment of visceral pain are provided. The salts of the present invention are particularly useful in the treatment of conditions characterized by abdominal pain, such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), diabetic gastroparesis, and dyspepsia.

Salts of trimebutine and N-desmethyl trimebutine

The present invention provides L-arginine salts of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these L-arginine salts of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of an inflammatory condition of the GI tract such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS).

Salts of 4- or 5-aminosalicylic acid

Method for the detection of gastric epithelial damage

Disclosed is a method for the detection of gastric epithelial damage and a method which is performed by administering a disaccharide to a patient, assaying the patient's blood or urine for the presence of the disaccharide and correlating the determined disaccharide assay value to gastric epithelial damage.

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Cochrane, Canada

John L Wallace