Fisons Ltd.

Frisons Limited

John L Suschitzky

David Cox

David Rutherford

Anthony Howard Ingall

David E Hall

Hugh Cairns

Kenneth J Gould

Hossein A Dowlatshahi

Nigel Chadwick

Ian D Dicker

David W Payling

Compounds of formula I, ##STR1## in which A is a 5 or 6 membered, fully unsaturated, carbocyclic or heterocyclic ring,

2-Pyridinyl-phenyl-sulphinyl-and-phenyl-thio-benzimidazoles having

There are described compounds of formula I, ##STR1## in which A is a benzene or heterocyclic ring, y is 0 or 1,

Certain 2-pyridinyl-phenylsulfinyl-benzoxazoles, the corresponding

There are provided benzopyrans of formula I, ##STR1## wherein the substituents, R.sub.5 -R.sub.8 and EA are as defined in the specification. These compounds are useful as anti-asthmatic agents.

Quinoline derivatives and their use as anti-asthmatic agents

There are provided benzopyrans of formula I ##STR1## wherein R.sub.6 and R.sub.7 together form the chain --CHOCH.dbd.(A.sub.1 E.sub.1)--O-- in which --O-- is attached to R.sub.7,

Dioxo dibenzopyrans and anti-allergic use thereof

There are described compounds of formula I, ##STR1## in which an adjacent pair of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --CZC(G.sub.1).dbd.(G.sub.2)--Z--,

Pyranoquinolinones and analogs thereof

There is described the mono salt of 6-methylamino-4-oxo-10-propyl-4H-pyrano[3,2-g]-quinoline-2,8-dicarboxylic acid with a strongly basic cation. There is also described an aqueous solution of 6-methylamino-4-oxo-10-propyl-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid the solution being at a pH of from 4 to 8. The salts and solutions are useful as pharmaceuticals, e.g. in the treatment of allergies.

Anti-allergic mono salt of

There are described compounds of formula I, ##STR1## IN WHICH R is allyl, chlorine, bromine, phenyl, or phenyl substituted by one or more halogen or alkyl groups, One of X and Y is a group --CO--, --CHOH-- or --CH.sub.2 -- and the other is an exocyclic carbon-carbon bond linking the ferrocenyl or the R group respectively to the --A-- group, A contains 5, 6 or 7 carbon atoms and is an ethylenically unsaturated (the double bond being connected to the carbon atom which is connected to X), unsubstituted (except by X and Y) cyclic hydrocarbon group; or is a saturated cyclic hydrocarbon group substituted by X and Y and, when X is a group --CO--, optionally substituted on the carbon atom to which Y is attached by an --OH group, and X and Y are attached to adjacent carbon atoms on the A group. There are also described processes for the production of compounds of formula I and haematinic compositions containing them.

Treating iron deficiency anaemia

There are described compounds of formula I, ##SPC1##

Compounds

There are described compounds of formula I, ##SPC1## in which R is alkyl, chlorine, bromine, phenyl, or phenyl substituted by one or more halogen or alkyl groups, One of X and Y is group --CO--, --CHOH-- or --CH.sub.2 -- and the other is an exocyclic carbon-carbon bond linking the ferrocenyl or the R group respectively to the -A- group, A contains 5, 6 or 7 carbon atoms and is an ethylenically unsaturated (the double bond being connected to the carbon atom which is connected to X), unsubstituted (except by X and Y) cyclic hydrocarbon group; or is a saturated cyclic hydrocarbon group substituted by X and Y and, when X is a group --CO-, optionally substituted on the carbon atom to which Y is attached by an -OH group, and X and Y are attached to adjacent carbon atoms on the A group. There are also described processes for the production of compounds of formula I and haematinic compositions containing them.

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Loughborough, United Kingdom

John L Suschitzky