Sloan-Kettering Institute for Cancer Research

Sloan-Kettering Institute

John L Lewis, Jr

Lloyd J Old

Carlos Cordon-Cardo

M Jules Mattes

Kenneth O Lloyd

Wolfgang J Rettig

Herbert F Oettgen

Katherine Look

Kenneth O Floyd

John P Koulos

Three new monoclonal antibodies, MU78, MT334, and MQ49, and the hybridoma cell lines producing these, are disclosed. The antibodies specifically bind to mucin-like antigens with distribution over various carcinomas.

Monoclonal antibodies to mucin-like human differentiation antigens

Monoclonal antibodies to specific cell surface antigens of human choriocarcinoma, teratocarcinoma, and normal trophoblasts are disclosed. Additionally, panels of monoclonal antibodies which may be used in phenotyping cell and tissue samples are disclosed as well.

Choriocarcinoma monoclonal antibodies and antibody panels

Mouse monoclonal antibodies to several cell antigens of human ovarian, cervical and endometrial carcinomas have been produced and characterized. The distribution of the antigens was determined by mixed hemagglutination assays on 153 normal and malignant cell cultures of various types, and by immunoperoxidase staining of frozen sections of 27 normal adult and 24 fetal tissues. five monoclonal antibodies representative of five classes of mAb raised to restricted ovarian, cervical and endometrial cells were tested extensively producing mAb reactive with cancer but not normal cells. One such mAb, MF116 was readily detected in the spent culture medium of metabolically radiolabeled cells. These antibodies, reacting with relatively restricted cell surface antigens, are useful in the analysis of epithelial cell differentiation, in cancer diagnosis and therapy and in tissue typing of normal or abnormal cells.

Monoclonal antibodies to ovarian, cervical and uterine human cancers and

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New York, NY, United States of America

John L Lewis, Jr