Syntex (u.s.a.) Inc.

Merrell Pharmaceuticals, Inc.

Merrell Dow Pharmaceuticals

Other

Aventis Pharma Limited

John L. Krstenansky

John L Krstenansky

John J Nestor, Jr

Brian H Vickery

Simon J Mao

Teresa H Ho

Chinh T Bach

Robert J Broersma

James R McCarthy

Scott L Harbeson

Stephen H Buck

Thomas J Owen

Chester F Hassman, Iii

Brian Henry Vickery

John Joseph Nestor, Jr

Michael Lloyd Radomsky

Christin Teresa Piazza

James R Mccarthy

Chester F Hassman

Simon Jt Mao

Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic .alpha.-helix, said residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence:

Analogs of parathyroid hormone and parathyroid hormone related peptide:

This invention relates to peptide derivatives which are useful anticoagulant agents.

Anticoagulant peptides

A pharmaceutical composition for the nasal delivery of compounds useful for treating osteoporosis, comprising an effective amount of a physiologically active truncated analog of PTH or PTHrp, or salt thereof, in which amino acid residues (22-31) form an amphipathic .alpha.-helix, said residues (22-31) selected from (SEQ ID NOS: 85, 86, 26, 27, 28, 29, and 30); an absorption enhancer selected from the group consisting of dimethyl-.beta.-cyclodextrin and the bile acid surfactants; and water is provided.

Pharmaceutical compositions for the nasal delivery of compounds useful

Synthesis and use for the treatment of osteoporosis

Analogs of parathyroid hormone and parathyroid hormone relate peptide

A method for controlling the growth of tumor tissues, especially small cell lung. Treatment comprises administering to a patient in need thereof, an effective amount of a bombesin/GRP type inhibitor. Antagonists of bombesin/GRP which are derivatives of naturally occurring bombesin/GRP possessing a thiomethylene or methylene sulfoxide bond connecting the two amino acids on the carboxy terminal end is modified are described. The antagonism is confirmed using conventional competitive binding and biochemical assays as well as conventional physiological tests and the use of these derivatives in a variety of conditions in which bombesin/GRP is implicated is also described.

Compounds and pharmaceutical uses of peptides of bombesin and GRP

Antagonists of neurokinin A which are derivatives of naturally occurring neurokinin A in which the amide bond connecting the two amino acids on the carboxy terminal end is modified are described. The antagonism is confirmed using conventional competitive binding and biochemical assays as well as conventional physiological tests and the use of these derivatives in a variety of conditions in which neurokinin A is implicated is also described.

Neurokinin A antagonists

Process for recombinant production of PTH and PTHrp analogs

Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic .alpha.-helix, these residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence:

Novel compounds which contain a thrombin catalytic-site inhibitor coupled with an anion binding exosite associating moiety via an RGD-X bridging sequence are trifunctional anticoagulants useful in treating venous or arterial thrombotic conditions.

Trifunctional antithrombin and antiplatelet peptides

Analogs of hirudin having anti-platelet activity

Growing community of inventors

Palo Alto, CA, United States of America

John L Krstenansky