Merck + Co., Inc.

University of Kansas

Silvergate Pharmaceuticals Inc.

Nps Pharmaceuticals, Inc.

Silvergate Pharmacauticals, Inc.

John L Haslam

Roger A Rajewski

Lian G Rajewski

Takeru Higuchi

Robert Mauro

Peter Colabuono

Kathleen Heppert

Michael C Beckloff

Arthur R Mlodozeniec

Frank Segrave

Gerald S Rork

James D Pipkin

Thomas B Marriott

Stefano A Pogany

Alexander E Forbes

Frank Seagrave

David S Wells

Provided herein are stable enalapril powder compositions for oral liquid formulation. Also provided herein are methods of using enalapril oral liquid formulations for the treatment of certain diseases including hypertension, heart failure and asymptomatic left ventricular dysfunction.

Enalapril compositions

The present disclosure provides rapidly dissolving oral capsules and films comprising pullulan, a plasticizer, and a dissolution enhancing agent.

Rapidly dissolving pharmaceutical compositions comprising pullulan

The present invention provides an orally dissolving capsule comprising pullulan, a plasticizer and a dissolution enhancing agent.

Sustained-release compositions for delivering therapeutic concentrations of isovaleramide, isovaleric acid, and certain structurally related compounds are provided for the treatment for a variety of pathological conditions, including epilepsy and spasticity, which are ameliorated by effecting a modulation of CNS activity. The ability of the compositions to sustain relatively constant levels of the drug at a therapeutic dose in the serum for extended periods of time enables a once or twice daily administration schedule.

Sustained-release formulations for treating CNS-mediated disorders

The instant invention is directed to a multiparticulate osmotic pump, for the controlled release of diltiazem L-malate to an environment of use, said pump comprising:

Multiparticulate controlled porosity osmotic pump

The instant invention is directed to an osmotic pump, for the controlled release of diltiazem L-malate to an environment of use, said pump comprising:

Controlled porosity osmotic pump

This invention relates to an eyeglass frame mounted unit dose ophthalmic drug delivery device. A unit dose of ophthalmic medicament is provided by either a preloaded disposable microsyringe, preloaded disposable tip or manually loaded calibrated microsyringe rigidly mounted on a block which itself is slidably mounted to the eyeglass frame. The device allows for the insertion of ophthalmic medication into the inferior cul de sac of the eye.

Eye frame ophthalmic drug delivery device

This invention involves complexes of quinoline carboxylic acid derivatives with guanidine and guanidine carbonate. The complexes have a greater solubility and dissolution rate when compared to the parent quinoline carboxylic acid derivatives and thus are more effective anti bacterials than the parent acids.

Quinoline carboxylic acid complexes with guanidinium carbonate

This invention relates to a unique drug delivery system for delivering drugs to a body cavity. The drug delivery system comprises a medicament and a polymer such that the drug delivery system is a liquid at room temperature but forms a semi-solid or gel at the body temperature in the body cavity.

Drug delivery system utilizing thermosetting gels

Present invention provides a unique drug delivery device for delivering drug by injection into a body. The drug delivery system comprises the drug and polymer which is a liquid at room temperature and a semi-solid or gel at the body temperature.

This invention describes the application of selected polymers as novel drug delivery systems which use the body temperature and pH to induce a liquid to gel transition of the polymer which contains a drug or therapeutic agent therein. The goal of such a delivery system is to achieve a greater degree of bioavailability or sustained concentration of a drug.

Ophthalmic drug delivery system utilizing thermosetting gels

This invention relates to a unique drug delivery system for application to the skin which drug delivery system is a liquid at room temperature, but when administered topically to the skin becomes a semi-solid or gel when warmed by the body.

Growing community of inventors

Lawrence, KS, United States of America

John L Haslam