Boston Scientific Scimed, Inc.

Cardiac Pacemakers, Inc.

John Kummailil

Joseph T Delaney, Jr

Paul J Smith

Gary Kappel

Samuel Raybin

Paul Smith

Tatyana Dyndikova

Paul Vincent Grosso

Carey Rehder

Nathaniel McCaffrey

Thomas M Ragonese

Federico Gutierrez

Robert B Devries

Robert B DeVries

Francis MacNamara

Matthew B Hollyer

Matthew P Jones

Yen-Hao Hsu

Sverre Gropen

Francis T MacNamara

Joseph T Delaney

Gary S Kappel

In some aspects, the present disclosure pertains to a multi-arm polymer comprising a core and a plurality of polyoxazoline segments (or arms) having a first end that is covalently attached to the core and a second end comprising a moiety that comprises a reactive group. In some aspects, systems are provided that comprise a first composition comprising such a multi-arm polymer and a second composition comprising a multifunctional compound that comprises functional groups that are reactive with the reactive groups of the multi-arm polymer. In some aspects, systems are provided that comprise crosslinked reaction products of such a multi-arm polymer and such a multifunctional compound.

Multi-armed polyoxazolines and compositions, systems and methods pertaining to the same

In some aspects, the present disclosure pertains to multi-arm polymers that comprise a core, a plurality of polymer segments having a first end that is covalently attached to the core and a second end comprising a moiety that comprises a reactive group, wherein the polymer segments comprise one or more free-radical-polymerizable monomers. In some aspects, systems are provided that comprise a first composition comprising such a multi-arm polymer and a second composition comprising a multifunctional compound that comprises functional groups that are reactive with the reactive groups of the multi-arm polymer. In some aspects, systems are provided that comprise crosslinked reaction products of such a multi-arm polymer and such a multifunctional compound.

Multi-armed polymers comprising free-radical-polymerizable monomers and compositions, systems and methods pertaining to the same

A method of forming an energy delivery portion of a medical device includes contacting a distal portion of an electrode shaft with an insulating material, and heating the insulating material to couple the insulating material to the distal portion of the electrode shaft to form an insulation tip. The distal portion of the electrode shaft includes one or more surface contours to entrain the insulating material.

Medical devices and related methods

Methods of treating a substrate, e.g., forming a coating on the substrate, are described. The method may include applying a solution comprising a multifunctional molecule or a multifunctional-polymer molecule to at least a portion of a surface of the substrate. The surface may comprise a metal or metal alloy and the multifunctional molecule or a multifunctional-polymer molecule may bond to the surface via at least one sulfur group of a plurality of sulfur groups of the multifunctional molecule. The method may include combining the multifunctional molecule with a polymer molecule to form the multifunctional polymer molecule before or after applying the solution. The polymer molecule may bond to an internal carbon group or a terminal sulfur group of the multifunctional molecule.

Coating compositions and related devices and methods

The present disclosure relates to injectable compositions sterile injectable fluid compositions comprising a polysaccharide having a color in the visible spectrum, methods of forming the same, kits containing the same, and methods for performing agent-assisted procedures in a patient using the same.

Injectable compositions

In some aspects, the present disclosure pertains to multi-arm polymers that comprise a core and a plurality of polymer segments having a first end that is covalently attached to the core and (a) a second end comprising a moiety that comprises a reactive end group, wherein the polymer segments comprise one or more hydrophilic aprotic NMP-polymerizable monomers, and wherein the reactive multi-arm polymer comprises nitroxide radicals or (b) a second end comprising a moiety that comprises an alkoxyamine group, wherein the core is a polyol residue, and wherein the polymer segments comprise one or more NMP-polymerizable monomers. In some aspects, the present disclosure pertains to a multifunctional alkoxyamine molecule comprising a core and a plurality of alkoxyamine groups covalently attached to the core, wherein the core is a polyol residue.

Multifunctional nitroxide-mediated polymerization initiators and multi-armed polymers and hydrogels formed therefrom

A medical device for insertion or implantation in a body includes a polymer substrate and a layer of poly(vinyl pyrrolidone-alt-maleic anhydride) formed on a surface of the polymer substrate. Polymer chains of the poly(vinyl pyrrolidone-alt-maleic anhydride) are entangled with the polymer substrate.

Hydrophilic coatings through in situ surface polymerization

A method of calibrating an image sensor may include detecting a response from a pixel of the image sensor as a result of light having an intensity impinging on the pixel, and measuring the actual standard deviation of the response of the pixel at the intensity of light. The method may also include determining an averaging number for the pixel at the intensity. The averaging number may be a number of responses of the pixel at the intensity to be averaged to attain an average response having a standard deviation less than or equal to a target value. The method may further include determining the average response of the pixel using the determined averaging number.

Image sensor calibration

An articulating portion for an elongate medical device is disclosed. The articulating portion may include a plurality of segments movable relative to one another, and a plurality of hinges disposed between adjacent segments. The segments can be configured to bend at the hinges upon manipulation of a control member of the device. The segments and the hinges can also be a single continuous piece of material.

Growing community of inventors

Sherborn, MA, United States of America

John Kummailil