The University of Arizona

Dupont Nutrition Biosciences Aps

John Konhilas

Meredith Hay

Robin L Polt

Evan Jones

Lajos Szabo

Todd Vanderah

Brittany Forte

Tally Milnes

Sampo Lahtinen

Lotta Stenman

Carol Barnes

The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and pain.

Ang (1-7) derivative oligopeptides for the treatment of pain

The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/of impairment.

Ang (1-7) derivative oligopeptides and methods for using and producing the same

This invention relates to new uses of(particularly, although not exclusively, probiotic), and to food products, feed products, dietary supplements and pharmaceutical formulations containing them. The bacteria are suitable for the treatment of myocardial infarction, dilated cardiomyopathy, inflammatory heart disease (including endocarditis, inflammatory cardiomegaly and myocarditis), and congestive heart failure.

Bifidobacteria for treating cardiac conditions

The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/or impairment, pain, and traumatic brain injury.

Ang-(1-7) derivative oligopeptides for the treatment of pain and other indications

The present invention provides compositions and methods for treating cognitive impairment or dysfunction in a subject. In particular, the present invention provides a method for using a composition comprising an angiotensin-(1-7) receptor agonist to treat cognitive dysfunction or impairment that is due to a various clinical conditions including, but not limited to, those associated with increase in inflammation, cytokine production, increases in reactive oxygen species, changes in expression of brain inflammatory related genes and/or in the expression of genes involved in learning and memory within the central nervous system of a subject.

Method for treating cognitive dysfunction

Ang-(1-7) derivative oligopeptides and methods for using and producing the same

ANG-(1-7) derivative oligopeptides and methods for using and producing the same

Growing community of inventors

Tucson, AZ, United States of America

John Konhilas