Merck Sharp + Dohme Corp.

Merck Sharp + Dohme B.v.

John Kinnaird Ferguson Maclean

Simon James Anthony Grove

Ronald Palin

Craig Jamieson

Jonathan Gillespie

Angus John Morrison

Duncan Robert McArthur

Julia Adam

Steven Laats

The invention relates to amino-heteroaryl derivatives having the general Formula I or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same, as well as to the use of these derivatives for the treatment of pain, such as neuropathic pain or inflammatory pain. 

Amino-heteroaryl derivatives as HCN blockers

The present invention relates to a heterocyclic derivative of formula (I) wherein the variables are as defined in the specification, or to a pharmaceutically acceptable salt or solvate thereof. The present invention further relates to pharmaceutical compositions comprising said heterocyclic derivatives and to their use in therapy, for instance in the treatment or prevention of disorders mediated by glutamate dysfunction, such as schizophrenia and generalised anxiety disorder. 

Heterocyclic derivatives

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Brookline, MA, United States of America

John Kinnaird Ferguson Maclean