Fisons Ltd.

John King

Hugh Cairns

Joachim Augstein

Dennis Hunter

Richard Hazard

Thomas B Lee

There is described the compound of formula I, ##STR1## and pharmaceutically acceptable derivatives thereof. Processes for making the compound and pharmaceutical, e.g. anti-asthmatic, compositions containing it are also described.

5-(2-Hydroxypropoxy)-8-propyl-4H-1-benzopyran-4-one-2-carboxylic acid

There are described compounds of formula I, ##STR1## in which R.sub.5, R.sub.6, R.sub.7 and R.sub.8, which may be the same or different, are hydrogen, alkyl C2 to 6, alkoxy C2 to 8, hydroxy-alkoxy C3 to 8, and R.sub.5 may be hydroxy, provided that one or two of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are other than hydrogen, and pharmaceutically acceptable derivatives thereof. The compounds of formula I are indicated for use in the treatment of asthma, and pharmaceutical compositions containing them and processes for their preparation are also described.

Benzopyranyltetrazoles as antiasthma agents

There are described compounds of formula I, ##STR1## and pharmaceutically acceptable derivatives thereof, in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are the same or are different and each is a hydrogen or halogen atom or an alkyl, hydroxy, alkoxy, or substituted alkyl or alkoxy group, (for example a hydroxy-alkoxy, alkoxyalkoxy or carboxyalkoxy group), and X is a saturated or unsaturated, substituted or unsubstituted, straight or branched hydrocarbon chain which may be interrupted by a carbocyclic or heterocyclic ring, or by one or more oxygen atoms or carbonyl groups. There are also described processes for making the compounds and pharmaceutical compositions, for the treatment of asthma, containing the compounds.

The treatment of asthma, hay fever or urticaria

Pharmaceutical compounds of formula I, ##SPC1## in which

1-Thiachromone-2-carboxylic acids and derivatives

There are described compounds of formula I, ##SPC1## in which

Benzopyranyltetrazoles

There are described compounds of formula I, ##SPC1##

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Loughborough, United Kingdom

John King