Saint Louis University

The University of Oklahoma

Pharmacia & Upjohn Company

John K Walker

Thomas Burris

Keith McCormick Haynes

John Nicholas Freskos

David Louis Brown

Yvette M Fobian

Michael B Tollefson

Andrew Simon Bell

Robert Owen Hughes

Dafydd Rhys Owen

Brent V Mischke

Michael John Palmer

E Jon Jacobsen

Todd M Maddux

David Graham Brown

John M Molyneaux

Christopher Phillips

Helen I Zgurskaya

Joseph B Moon

Narges Abdali

D Joseph Rogier, Jr

Valentin V Rybenkov

Arindam Chatterjee

Colin Flaveny

Carissa S Hampton

Cyrielle Billon

Steven E Heasley

Sadichha Sitaula

Kristine Griffett

In one aspect, the present disclosure describes new estrogen receptor-related orphan receptor (EER) inverse agonist compounds. Also described are pharmaceutical formulations, methods of synthesis and uses thereof.

Modulators of the estrogen-related receptor

In some aspects, the present disclosure provides compounds of the formula: (I) or (II) wherein the variables are as defined herein. In some embodiments, these compounds may be used to treat cancer or other hyperproliferative diseases, as well as atherosclerosis and coronary artery disease.

LXR inverse agonists for treatment of cancer

Described are compounds and methods useful in measuring membrane permeability and efflux transporter activity in bacteria, including multidrug resistance Gram negative bacteria.

Fluorescent probes for drug permeability in gram negative bacteria

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: wherein R, R, Rand Rare as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, synthetic methods, and intermediates are also disclosed.

Pyridine [3,4-b] pyrazinones

Growing community of inventors

St. Louis, MO, United States of America

John K Walker