Level 3 Communications, LLC

D.e. Shaw Research, LLC

Level 3 Cdn International, Inc.

John K Salmon

Jeffrey G Koller

Maksim Yevmenkin

Mark Brady

Paul Ernest Stolorz

Michael S Warren

David Pfitzner

Ted Middleton

Aric Hagberg

Martin M Deneroff

David E Shaw

Ron Dror

Richard H Larson

Paul Maragakis

Peter Skopp

Hunter Nisonoff

Paul E Stolorz

David Pfilzner

Discovering molecules (which may be known or may never have been cataloged or ever synthesized) that have desired characteristics is addressed using a machine learning approach. As compared to a brute-force search of a database of known molecules, which may not be computationally feasible, the present machine learning approach renders identification of both known and unknown molecules computationally tractable. Furthermore, the computational effort is largely shifted to training of the machine learning system using a database of known molecules, and the generation of molecules to match any particular characteristics requires relatively little computation. The molecules using the present approach may be further studied, for example, with computer-based simulation or after physical synthesis using biological experimentation to ultimately yield useful chemical compounds.

Molecular graph generation from structural features using an artificial neural network

A network includes a first tier of servers, a second tier of servers and a third tier of servers. The first tier of servers comprises a plurality of primary servers capable of responding to requests. The plurality of primary servers includes at least one dynamic server having a load share characteristic that is dynamically altered during a first period in time and at least one static server having a constant load share characteristic during the first period in time. The second tier of servers includes at least two first layer overflow servers. Each of the first layer overflow servers is configured to provide response duties in the event that one or more of the primary servers is unavailable or overloaded. The third tier of servers comprising at least two second layer overflow servers. Each of the second layer overflow servers is configured to provide response duties in the event that one or more of the primary servers is unavailable or overloaded and one or more of the first layer overflow servers is unavailable or overloaded.

Multi-tiered server network

A method includes monitoring the operational status of at least some name servers in a name server network. Based on the monitoring, when an error or anomalous condition is detected at a particular name server, creating a policy to indicate the status of the particular name server. The policy is taken into account when resolving hostnames using the name server network.

Detecting anomalous conditions in a name server network

A computation system for computing interactions in a multiple-body simulation includes an array of processing modules arranged into one or more serially interconnected processing groups of the processing modules. Each of the processing modules includes storage for data elements and includes circuitry for performing pairwise computations between data elements each associated with a spatial location. Each of the pairwise computations makes use of a data element from the storage of the processing module and a data element passing through the serially interconnected processing modules. Each of the processing modules includes circuitry for selecting the pairs of data elements according to separations between spatial locations associated with the data elements.

Parallel computer architecture for computation of particle interactions

A parallel processing system for computing particle interactions includes a plurality of computation nodes arranged according to a geometric partitioning of a simulation volume. Each computation node has storage for particle data. This particle data is associated with particles in a region of the geometrically partitioned simulation volume. The parallel processing system also includes a communication system having links interconnecting the computation nodes. Each of the computation nodes includes a processor subsystem. These processor subsystems cooperate to coordinate computation of the particle interactions in a distributed manner.

Parallel processing system for computing particle interactions

A method, operable in a framework wherein resources of a content provider may be delivered to clients from at least two distinct content delivery networks (CDNs). Responsive to a client request, one of the CDNs is selected, the selection being based at least in part on one or more policies set by the content provider. The client is provided with information associated with the selected CDN. The information may be a domain name such as a CNAME for the selected CDN. The policies may include a load share policy that specifies a relative load share for each CDN, and the selecting may attempt to satisfy the load share policy. Updated content provider policies may be obtained, at regular intervals.

Distributing requests across multiple content delivery networks based on subscriber policy

In a framework wherein resources of a content provider may be delivered to clients from different domains, a method distributes the requests based on content-provider policies. In some cases, the domains include at least two distinct content delivery network (CDN) domains. The domains may include a content provider domain. Responsive to a request, either the content provider domain or one of the two CDN domains is selected, the selection being based at least in part on one or more policies set by the content provider.

Policy-based content delivery network selection

A framework for delivery of Internet content includes a subscriber server network; and at least one domain name server constructed and adapted to provide policy-based domain name service, wherein, in response to a request to resolve a hostname, the domain name server resolves the hostname to at least one address corresponding a server in the subscriber server network based on at least one policy consideration. The framework may include a content delivery network, distinct from the subscriber server network, wherein, in response to a request to resolve a hostname, the domain name server provides at least one addresses of a server in the content delivery network based at least on the location of the requestor and other policy considerations. An address returned by the domain name server is selected based on one or more of: (a) geographic policies; (b) load share policies; (c) overflow policies; and (d) network aware policies.

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Chappaqua, NY, United States of America

John K Salmon