Theranos, Inc.

Matsushita Electric Industrial Co., Ltd.

Labrador Diagnostics LLC

Matsushita Electronic Industrial Co., Ltd

John K Howard

Elizabeth A Holmes

Shaunak Roy

Timothy Michael Kemp

Ian Gibbons

Chengwang Wang

Shulin Zeng

Chris Todd

Jeff Fenton

Ron Oral

Jean-Claude Junqua

Shize Daniel Qi

Dwayne Escola

Jim Pollock

This invention is in the field of medical devices. Specifically, the present invention provides fluidic systems having a plurality of reaction sites surrounded by optical barriers to reduce the amount of optical cross-talk between signals detected from various reaction sites. The invention also provides a method of manufacturing fluidic systems and methods of using the systems.

Fluidic medical devices and uses thereof

This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.

System and methods for analyte detection

The invention relates to an ingestible, implantable or wearable medical device comprising a microarray which comprises a bioactive agent capable of interacting with a disease marker biological analyte; a reservoir which comprises at least one therapeutic agent and is capable of releasing the therapeutic agent(s) from the medical device; and a plurality of microchips comprising a microarray scanning device capable of obtaining physical parameter data of an interaction between the disease marker biological analyte with the bioactive agent; a biometric recognition device capable of comparing the physical parameter data with an analyte interaction profile; optionally a therapeutic agent releasing device capable of controlling release of the therapeutic agent from the reservoirs; an interface device capable of facilitating communications between the microarray scanning device, biometric recognition device and the therapeutic agent releasing device; and an energy source to power the medical device. Specifically, the invention relates to a medical device capable of detecting an analyte in a bodily fluid comprising at least one microneedle capable of obtaining a sample of a bodily fluid, a first microchannel through which the sample flows and is in fluid communication with the at least one microneedle, a second microchannel in fluid communication with the first microchannel, through which a buffer flows, wherein the second channel comprises a microarray with a bioactive agent, a microarray scanning device to detect an interaction between the bioactive agent and the analyte in the bodily fluid; and an interface device.

Medical device for analyte monitoring and drug delivery

Systems and methods for conducting animal studies

Systems and methods for improving medical treatments

Point-of-care fluidic systems and uses thereof

A control system including a portable device and a server. The portable device includes: (1) a body; (2) a microphone for receiving a first audio data; (3) an audio coder for converting the first audio data to first audio data signals; (4) an optical sensor for reading a first optical data; (5) an optical coder for converting the first optical data to first optical data signals; and (6) a transmitter for transmitting at least the first audio data signals or the first optical data signals to the server. The server includes: (1) a communication device for receiving at least first audio data signals or the first optical data signals transmitted by the transmitter; (2) a data analyzer for extracting semantic information from the first audio data signal and for converting the semantic information into an audio command; (3) an optical analyzer for converting the first optical data to an optical command; (4) a memory device for storing programs to be performed; and (5) a CPU for receiving the audio command and the optical command, retrieving a program associated with the audio command or the optical command and for executing the retrieved program.

Method and apparatus for communicating between a portable device and a server

An apparatus for identifying an unknown DNA sample. The apparatus includes a plurality of detection nodes, each of which is operable for allowing an interaction between a known DNA sample and an unknown DNA sample, and for generating an output signal if hybridization occurs between the known DNA sample and the unknown DNA sample. The apparatus further includes a decoder operative for receiving an input signal indicative of which of the plurality of detection nodes should be selected for processing and for outputting control signals which operate to activate the selected detection node. Further, each of the detection nodes includes a light source and a photodetection circuit. The photodetection circuit has a conductance value which varies if hybridization occurs between the known DNA sample and the unknown DNA sample deposited in the detection node. This change in conductance value is utilized to generate the output signal which indicates that hybridization has occurred.

Method and apparatus for detecting DNA hybridization

An apparatus for identifying an unknown DNA sample. The apparatus includes a plurality of detection nodes, each of which is operable for allowing an interaction between a known DNA sample and an unknown DNA sample, and for generating an output signal if hybridization occurs between the known DNA sample and the unknown DNA sample. The apparatus further includes a decoder operative for receiving an input signal indicative of which of the plurality of detection nodes should be selected for processing and for outputting control signals which operate to activate the selected detection node. Further, each of the detection nodes comprises a first floating gate transistor having a conductance value which varies if hybridization occurs between the known DNA sample and the unknown DNA sample contained in the first transistor. This change of conductance value is utilized to generate the output signal which indicates that hybridization has occurred.

In a first exemplary embodiment, the present invention relates to an apparatus for performing an assay comprising a micro-system platform, a CD-ROM device and an information processor, where the CD-ROM device under control of the information processor is capable of reading and writing data to the micro-system platform. The micro-system platform comprises a first section for storing data in a continuous circular data band, which is disposed in an inner portion of the micro-system platform, and a second section including at least one assay, which is formed in an outer portion of the micro-system platform. During operation, the CD-ROM device retrieves and stores data related to the performance of the assay in the circular data band. The information processor is operative for controlling the CD-ROM device in accordance with the data retrieved from the circular data band, and for analyzing the results of the assay.

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Saratoga, CA, United States of America

John K Howard