Abbott Cardiovascular Systems, Inc.

Intersect Ent Gmbh

University of Pittsburgh

Abbott Laboratories Corporation

Abbott Medical Optics Inc.

Johnson & Johnson Surgical Vision, Inc.

Neograft Technologies, Inc.

Fiagon Gmbh

John Joseph Stankus

Mikael Trollsas

Stephen D Pacetti

Michael H Ngo

Syed F Hossainy

Jinping Wan

James Su

Benjamyn Serna

Gene Michal

Shubhayu Basu

Dariush Davalian

Florian Ludwig

Richard Roy Newhauser, Jr

William Richard Wagner

Kevin Joe Ehrenreich

Jesus Magana

Syed Faiyaz Ahmed Hossainy

Randolf Von Oepen

Paul M Consigny

Anthony S Andreacchi

Binh T Nguyen

Lorenzo Soletti

Victoria May Gong

Syed F A Hossainy

Yunbing Wang

Lothar W Kleiner

Mohammed S El-Kurdi

J Christopher Flaherty

Bin Huang

Thierry Glauser

Irina Astafieva

Barbara E Stamberg

Stephen Francis Badylak

Eugene T Michal

Kyle Klein

Chad Joseph Abunassar

Yiwen Tang

Santosh V Prabhu

Anthony J Abbate

Travis Richard Yribarren

Evgenia Mandrusov

John L Toner

Yi Hong

Richard E Kaufman

David A Vorp

Florian Niklas Ludwig

Katsuyuki Murase

Michael J Leonard

Benny Serna

Yuet Mei Khong

O Mikael Trollsas

Hugh Zhao

Rachel Bright

Li Zhao

Jonathan McGrath

Dan Cox

Syed Fayaiz Ahmed Hossainy

Julia Fox

Pamela A Kramer-Brown

David A Mackiewicz

Erik David Eli

Bozena Zofia Maslanka

Thomas W Gilbert

Donald O Freytes

Daniel Urbaniak

Nam D Pham

Jianjun Guan

Lyudmila Kokish

Sean Nicholas Finson

Joshua Smith

Liangxuan Zhang

Hong Ma

Brandon Katz

Diego Javier Garnica

Tu Duc Ngo

Rahul Bitla

Shadid Askar

Scott Perrin

Mohammed S El-Kurdl

Wen Chung Tsai

Daniel J Urbaniak

Lothar Walter Kleiner

Ed Berger

Jonathan Mcgrath

Sean Finson

Mikael O Trollsas

Systems and methods for delivering a therapeutic agent to target tissue using a plurality of drug delivery platforms each having a polymer scaffold and the therapeutic agent contained within the polymer scaffold. Each drug delivery platform of the plurality of drug delivery platforms is implanted into the target tissue, allowing the therapeutic agent to elute from each drug delivery platform of the plurality of drug delivery platforms for a target period of time, delivering a therapeutic dose of the therapeutic agent for the target period of time. Each drug delivery platform of the plurality of drug delivery platforms is allowed to biodegrade within the target tissue.

Submucosal bioresorbable drug eluting platform

Described here are devices, systems, and methods for treating conditions or diseases of the nose, ear, or throat with an expandable device having a drug coating. The expandable devices may be delivered to a body cavity in a low-profile configuration and expanded to contact surrounding tissue. The expandable devices may deliver or release the drug coating to the tissue. Multiple expansions of a single device may be employed during treatment. Various coating excipients and manufacturing parameters for the expandable devices may also be adjusted to enhance or slow transfer of the drug coating and/or release of the drug to the target tissue site. The drug transferred to the tissue may act as an in situ depot that enables maintenance of a therapeutic level of locally delivered drug for a desired time period after removal of the expandable devices.

Drug-coated balloon

A tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.

Bioerodible wraps and uses therefor

Described here are systems and methods for delivering an active agent to target tissues of the ear, nose, or throat using an expandable member having drug crystals layered thereon, and methods for manufacturing such systems. The expandable member can be delivered to the target tissues in a low-profile configuration and expanded to contact and/or dilate surrounding tissue. Expansion of the expandable member transfers the drug crystals to the target tissues, which then act as an in situ depot that enables maintenance of a therapeutic level of an active agent for a desired time period after removal of the expandable member. Multiple expansions of a single expandable member can be employed during treatment. For example, the systems and methods can be useful when it is desired to treat multiple paranasal sinuses with a single expandable member.

Expandable member systems and methods for drug delivery

Bioabsorbable scaffolds having high crush recoverability, high fracture resistance, and reduced or no recoil due to self expanding properties at physiological conditions are disclosed. The scaffolds are made from a random copolymer of PLLA and a rubbery polymer such as polycaprolactone.

Shape memory bioresorbable polymer peripheral scaffolds

A method for manufacturing a shaping structure having a generally helical profile and configured to support electrodes for delivering electric energy into a cylindrical lumen of a patient. The method comprises providing a mandrel with a circular cylindrical shape and forming a first hole in the mandrel along the elongate axis, such that opposing ends of a bore of the first hole emerge at the proximal end and at the distal end; forming a second hole in the mandrel to extend from the curved surface to connect with the first hole; wrapping a metal wire around the mandrel; and inserting opposing ends of the metal wire into the second and the third hole respectively, and threading the opposing ends of the metal wire until they emerge from the opposing ends of the bore of the first hole; finally, heating the mandrel and the wire.

System for denervation

This application is generally related to systems and methods for accessing the paranasal sinuses and other passages of the nose, ear, and throat. The systems and methods generally employ devices capable of maintaining a fixed handle orientation with respect to the patient while generating the appropriate applicator deflection angle required to rotationally align or orient the applicator tip to the intended target tissue/anatomy for treatment. Methods are also described for deploying drug delivery devices within these body structures using the systems to treat medical conditions associated therewith.

Systems and methods for sinus access

Method of manufacturing a shaping structure for denervation

A medical device-includes a scaffold crimped to a catheter having an expansion balloon. The scaffold is crimped to the balloon by a process that includes one or more balloon pressurization steps. The balloon pressurization steps are selected to enhance scaffold retention to the balloon while retaining, at least partially, the original balloon folds as the balloon is pressurized and de-pressurized within a crimper head. By at least partially retaining the original balloon folds, a uniformity of scaffold expansion by the balloon is improved.

Methods for uniform crimping and deployment of a polymer scaffold

An ophthalmic shunt includes a seal or septum through which multiple injections of the therapeutic agent can be made as needed, thereby avoiding repeated injury to the sclera. The therapeutic agent is temporarily carried in a tube connected to the septum. The therapeutic agent release may be rapid or sustained over a period of time.

Ophthalmic shunt and method

A system and method for coating an expandable member of a medical device comprising a support structure to support the expandable member and a dispenser positioned with at least one outlet proximate a surface of an expandable member. A drive assembly establishes relative movement between the at least one outlet and the surface of the expandable member to apply fluid on the surface of the expandable member along a coating path. A guide maintains a substantially fixed distance between the at least one outlet and the surface of the expandable member during relative movement therebetween by displacing the expandable member relative to the at least one outlet.

Maintaining a fixed distance during coating of drug coated balloon

Growing community of inventors

Campbell, CA, United States of America

John Joseph Stankus