Advanced Micro Devices Corporation

Eisai R&d Management Co., Ltd.

Other

Monsanto Technology LLC

Irobot Corporation

Linkedin Corporation

Verity, Inc.

Irobot Defense Holdings, Inc.

Fujitsu Corporation

Yahoo! Inc.

Flashpoint Technology, Inc.

Advance Micro Devices, Inc.

Advanced Micro Device, Inc.

Fujitsu Amd Semiconductor Limited

Monsanto Europe S.a.

John JianShi Wang

Kent Kuohua Chang

Hao Fang

Nian Niles Yang

Ming-Hong Hao

Sudeep Prajapati

Yuesong He

Dominic J Reynolds

Zhigang Wang

Guo Zhu Zheng

Takashi Satoh

Lu You

Peter G Smith

Eric W Smith

Jiang Li

Yoshihiko Kotake

Gregg F Keaney

Jeffrey P Erhardt

Kazunobu Kira

Masaaki Higashitani

Parcharee Tivitmahaisoon

Norio Murai

Brent D Massmann

Baudouin Gerard

Xiang Liu

Orin P F Hoffman

Masayuki Miyano

Peter Keefe

Andrew Labrecque

Brett Ponsler

Susan Macchia

Brian J Madge

Mark G Bock

Michael K Templeton

Tien-Chun Yang

Paul J Steffan

Unsoon Kim

Xin Sheng Guo

Wenge Yang

Atsushi Endo

Susanta Samajdar

Kam-To Wan

Ping Zhu

Shivananda S Shetty

Yasuhiro Matsuda

Arani Chanda

Lihua Yu

Ermira Pazolli

Chanh Nguyen

Fei Wang

Angela Tai Hui

Richard M Fastow

Mark S Chang

Dawn M Hopper

Effiong Etukudo Ibok

Zhichen Xu

Yue-Song He

Yider Wu

Jianchang Mao

Kai Yang

Hyeon-Seag Kim

William H Miller

William Abraham

Andrew Cook

Chad P Walters

Jeffrey Alan Graham

Beth Jo Calabotta

Yimin Jiang

Marta Nevalainen

King Wai Kelwin Ko

Wiley Eugene Hill

Hong Du

Kristen Sanders

Huiming Zhang

Anand Selvaraj

Silvia Buonamici

Tho Le La

John H Ahn

Eunice Sun Park

Erik Schembor

Manav Korpal

Jason T Lowe

George Moniz

Xiang-Yi Li

Richard M Kramer

Wing Han Leung

Bruce Decosta

Artem Gritsenko

Kian Huat Lim

James Palacino

Kenneth Wo-Wai Au

Srikanth Sundararajan

Kenichi Nomoto

Kenshi Yoshida

Sergei I Agoulnik

Satoshi Nagao

Zacharias Psarakis

Esteban Kozak

Shelby Ellery

Salvatore F Cagnina

The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Certain pladienolide compounds and methods of use

An autonomous cleaning robot includes a controller configured to execute instructions to perform one or more operations. The one or more operations includes operating a drive system to move the cleaning robot in a forward drive direction along a first obstacle surface with a side surface of the cleaning robot facing the first obstacle surface, then operating the drive system to turn the cleaning robot such that the side surface of the cleaning robot faces a second obstacle surface, then operating the drive system to move the cleaning robot in a rearward drive direction along the second obstacle surface, and then operating the drive system to move the cleaning robot in the forward drive direction along the second obstacle surface.

Navigation of autonomous mobile robots

A number of crystalline forms of N-(2-((6-(3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-methylureido)pyrimidin-4-yl)amino)-5-(4-ethylpiperazin-1-y1)phenyl)acrylamide are provided. These include a crystalline free base form, a crystalline monohydrochloride salt form, a crystalline dihydrochloride salt form, and a crystalline ethanesulfonate salt form. Methods of making and using crystalline compounds are also provided.

Crystalline FGFR4 inhibitor compound and uses thereof

A system enables tool to process remote log files as if the log files were located locally. The system relies on technology, such a file system in user space (FUSE), to add log file search results to the local file system. In some embodiments, the log file search results are associated with virtual files in the local file system. A remote data store system communicates with the local system to provide the search results in response to a search query.

Incorporation of dynamic search results from a remote source into a local file system for log file analysis

Processes for producing 2,5-dichlorophenol and 3,6-dichloro-2-methoxybenzoic acid are described. Various processes for isomerizing 2,4-dichlorophenol over a zeolite catalyst to form 2,5-dichlorophenol are provided. Processes for preparing 2,5-dichlorophenol including hydroxylating 1,4-dichlorobenzene are also described. The present invention also relates to processes for producing 3,6-dichloro-2-methoxybenzoic acid.

Processes for preparing 2,5-dichlorophenol

Provided herein are compounds of Formula I useful as FGFR4 inhibitors, as well as methods of use of the same.

Pyrimidine FGFR4 inhibitors

Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compounds or pharmaceutically acceptable salts thereof. The breast cancer may be an ER-positive breast cancer and/or the subject in need of treatment may express a mutant ER-&#x3b1; protein.

Tetrasubstituted alkene compounds and their use

The present disclosure provides a novel solid state form of pladienolide pyridine compounds having Formula I, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful. 

Crystalline form of (2S,3S,6S,7R,10R,E)-7,10-dihydroxy-3,7-dimethyl-12-oxo-2-((R,2E,4E)-6-(piridin-2-yl)hepta-2,4-dien-2-yl)oxacyclododec-4-en-6-yl-4-methylpiperazine-1-carboxylate and methods of use thereof

A method of operating a robot includes electronically receiving images and augmenting the images by overlaying a representation of the robot on the images. The robot representation includes user-selectable portions. The method includes electronically displaying the augmented images and receiving an indication of a selection of at least one user-selectable portion of the robot representation. The method also includes electronically displaying an intent to command the selected at least one user-selectable portion of the robot representation, receiving an input representative of a user interaction with at least one user-selectable portion, and issuing a command to the robot based on the user interaction.

Remotely operating a mobile robot

A network update interface is presented to a user on a network to display network updates from other users of a mutual social-networking site. The network updates shared by the other users are gathered in a stream and supplied to a facet-filtering system including a network update interface. The user controls the display of certain network update items according to facet-filter characteristics enabled in facet-filter selection panels in the network update interface. The facet-filter characteristics are used by a facet filter to select certain network updates for display to the user in the network update interface. Trending links to further articles with content corresponding to the facet-filter characteristics are displayed to the user according to greatest popularity among the other users. Links to the profiles of the users sharing the articles are also provided in the network update interface.

Facet-based filtering of social network update data

Growing community of inventors

San Jose, CA, United States of America

John JianShi Wang