Chemocentryx, Inc.

John Jessen Wright

Solomon Ungashe

Zheng Wei

Andrew Pennell

Wei Yu Chen

Sreenivas Punna

Yibin Zeng

Andrew M K Pennell

Daniel J Dairaghi

Trevor T Charvat

Jimmie L Moore

Jeff Jin

Arindrajit Basak

Derek Hansen

Antoni Krasinski

Thomas J Schall

Qiang Wang

Anita Melikian

Brett Permack

Cheng Hu

Aaron Robert Novack

Solomon Ugashe

Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.

Heteroaryl sulfonamides and CCR2/CCR9

Compounds are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.

Aryl sulfonamides

Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of chemokine receptor-mediated diseases, and as controls in assays for the identification of chemokine antagonists.

Bis-aryl sulfonamides

Heteroaryl sulfonamides and CCR2

The present invention relates to compounds that modulate various chemokine receptors. These compounds are useful for treating inflammatory and immune diseases.

Substituted quinolone compounds and compositions are provided along with methods for the use of those compounds in the treatment of diseases and disorders such as cancer.

Substituted quinolones and methods of use

Growing community of inventors

Redwood City, CA, United States of America

John Jessen Wright