Innate Biotherapeutics, LLC

John James Kane

Gabriel Oscar Reznik

Hua Miao

James Michael Siedlecki

Ifat Rubin-Bejerano

Arthur F Kluge

Eric Steven Furfine

Isabelle Sansal-Castellano

Zuzana Dostalova

The present invention encompasses embodiments in which a therapeutic antibody is conjugated to β-1,6-glucan oligomers. Thus, the present invention includes, among other things, compositions including a therapeutic antibody conjugated to one or more β-1,6-glucan oligomers. The present invention further includes, among other things, methods of making and/or using such β-1,6-glucan conjugates. In certain embodiments, a β-1,6-glucan conjugate of the present invention is useful as a therapeutic or in a method of therapy.

ß-1,6-glucan therapeutic antibody conjugates

This invention relates to modifications of &#x3b2;-1,6-D-glucans, e.g., structures according to Formula (I), and the ability of these compositions to modulate an immune response. 

Immunomodulating beta-1,6-D-glucans

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Cambridge, MA, United States of America

John James Kane