Chinese Academy of Sciences

Shenzhen Forward Pharmaceuticals Co., Ltd.

Monsanto Company

Stephen R. Bertenshaw

Roland S. Rogers

David B. Reitz

John J. Talley

John J Talley

Stephen R Bertenshaw

David B Reitz

Xuan Yang

Yanmei Zhang

Micky D Tortorella

Yican Wang

Chuang He

Chenggang Zhu

Jiantong Guan

Chaochun Zhang

Chaole Chen

Yongjie Lin

Liming Bao

Liangliang Xu

The present application relates to azaaromatic amide derivatives for the treatment of cancer. Specifically, the present application relates to a preparation method and use of azaaromatic amide derivatives. The present application relates to azaaromatic amide derivatives and anilino-pyrimidine compounds represented by formula (I), formula (II), formula (III), formula (IV), and formula (V), and pharmaceutically acceptable salts thereof; the compounds or salts thereof can be used to treat or prevent a disease or disorder by regulating certain mutant forms of epidermal growth factor receptors. The present application also relates to a pharmaceutical composition comprising the compounds or salts thereof, and a method for treating various diseases mediated by EGFR, or HER2, or HER4 by using the compounds and salts thereof.

Azaaromatic amide derivatives for the treatment of cancer

Provided are a 4-sulfur pentafluoride phenol compound and a preparation method therefor, and a preparation method for a sulfur pentafluoride substituted benzopyran compound. According to the present invention, sulfur pentafluoride salicylaldehyde with multiple substituent groups is synthesized through a plurality of steps by using sulfur pentafluoride phenol as a raw material, and then the sulfur pentafluoride substituted benzopyran compound is synthesized on this basis. The method is simple and convenient, and low in cost; overcomes the defects that, at present, the number of types of sulfur pentafluoride phenols is small, and the synthesis of various sulfur pentafluoride substituted benzopyran compounds cannot be met; and has wide industrial application prospects.

4-sulfur pentafluoride phenol compound and preparation method therefor, and preparation method for sulfur pentafluoride substituted benzopyran compound

Growing community of inventors

Guangdong, China

John J Talley