American Home Products Corporation

Wyeth

John J Michelucci

Deborah M Sherman

Richard J DeNeale

Ronald N Warner

John Krupey

John C Clark

Arthur Hurwitz

A sustained release dosage form of etodolac is provided which is a tablet having as essential components etodolac, hydroxyproplymethylcellulose, ethylcellulose and a release rate modifying agent such as dibasic sodium phosphate, the hydroxyproplymethylcellulose having a hydroxypropoxyl content of about 7.0% to 8.6% by weight.

Sustained release etodolac

A calcium supplement compressed tablet containing at least about 80% by weight of tricalcium phosphate having incorporated therein as a disintegrant croscarmellose sodium and about 50% to 100% by weight based on the croscarmellose sodium of sodium lauryl sulfate.

Calcium supplement compressed tablets

At least two incompatible solutions are simultaneously charged into a container maintained at a temperature substantially below the freezing temperature of each solution in such predetermined amounts that the separate charges of solution freeze on the walls and are then lyophilized.

Method of producing multicomponent lyophilized product

Growing community of inventors

Plattsburgh, NY, United States of America

John J Michelucci