US Government As Represented by the Secretary of the Army

John J Martin

Harold Z Sommer

Emory W Sarver

Paul C Bossle

A method for the simultaneous detection, separation and analysis by reverse hase HPLC of sulfur mustard type compounds and their major hydrolysis and oxidation by-products utilizes a novel precolumn enhancement derivatization procedure. The method involves the reaction of these nonchromophoric sulfides with N-halogeno-N-metal arylsulfonamidates on a microscale to produce UV or visible absorbing or fluorescing arylsulfonylsulfilimine compounds. These arylsulfonylsulfilimine derivatives can then be readily separated on a low polarity C-18 column by reverse phase HPLC. The method permits quantitation of these sulfides by UV detector response in quantities as small as 20 nanograms.

High performance liquid chromatography (HPLC) analysis of sulfur

1. The method of determining the trajectory of a ballistic missile having trajectory substantially defined by the formula:

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South Bend, IN, United States of America

John J Martin