Alza Corporation

John J Leonard, Jr

Jeremy C Wright

Sally A Tao

James B Eckenhoff, Deceased

Cynthia L Stevenson

Steven J Prestrelski

Judy A Magruder

John P Carr

Leslie A Holladay

Iris K Leung

James B Eckenhoff

This invention relates to stable liquid aqueous formulations of peptide compounds at high concentrations. These stable formulations comprise at least about 10% peptide in water. They may be stored at elevated temperatures for long periods of time and are especially useful in implantable delivery devices for long term delivery of drug.

Aqueous formulations of peptides

This invention relates to stable non-aqueous protic formulations of peptide compounds. These stable formulations comprise peptide in non-aqueous protic solvent. They may be stored at elevated temperatures for long periods of time and are especially useful in implantable delivery devices for long term delivery of drug.

Non-aqueous protic peptide formulations

The present invention provides improved compositions for improving the chemical and physical stability of peptides and proteins. The invention provides a liquid beneficial agent formulation containing a liquid suspension comprising at least 5% by weight beneficial agent and having a viscosity and beneficial agent size which minimizes settling of the agent in suspension over the extended delivery period.

Peptide/protein suspending formulations

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Cupertino, CA, United States of America

John J Leonard, Jr