Infinity Pharmaceuticals, Inc.

Infinity Discovery, Inc.

John J Lee

James I Wright

Louis Grenier

Edward Holson

Brian C Austad

James R Porter

Roger H Pak

Provided herein, inter alia, are solid forms of geldanamycin analogs, pharmaceutical compositions comprising a geldanamycin analog and a crystallization inhibitor, methods of making and using such compositions. Additionally, provided are methods for the treatment of cancer, a neoplastic disease state and/or a hyperproliferative disorder, and methods of inhibiting Heat Shock Protein 90 ('Hsp90').

Ansamycin formulations and methods of use thereof

Amorphous, polymorphic, and solvated forms of 17-amino geldanamycin are disclosed. These compounds are particularly useful for the treatment of cancer, a neoplastic disease state and/or a hyperproliferative disorder, and inhibiting Heat Shock Protein 90 ('Hsp90').

Growing community of inventors

Somerville, MA, United States of America

John J Lee