Abbott Laboratories Corporation

John J Kyncl

Martin Winn

John F DeBernardis

Bruce W Horrom

R(+)-2-[4-[(tetrahydro-2-furanyl)carbonyl]-1-piperazinyl]-6,7-dimethoxy-4-q uinazolinamine hydrochloride or a pharmaceutically acceptable salt or hydratet hereof (terazosin), substantially free of the S(-)-enantiomer.

R(+)-terazosin

2-Fluoronorepinephrine has been found to have antihypertensive activity when orally administered to warm-blooded animals.

Antihypertensive method

Described is a method of increasing urinary excretion by administering effective amounts to a subject in need thereof of compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen, loweralkyl, lowercycloalkyl, aralkyl, aryl, pyridyl, isoquinolyl or phthalazinyl, or aryl substituted by one or more hydrogen, halo, loweralkyl, lowercycloalkyl, haloloweralkyl, aminosulfonyl, nitro, hydroxy, alkoxy, carboxy, alkoxycarbonyl, cycloalkoxy carbonyl, aminocarbonyl, diloweralkylaminocarbonyl or ##STR2## wherein n is 4 or 5.

Pyrazolyl amino imidazolines as diuretic agents

This invention provides aminomethylene oxindole compounds represented by the formula ##STR1## wherein R is H or loweralkyl; R' is loweralkyl, aralkyl, or R and R' taken together form a chain of the formula

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Lake Forest, IL, United States of America

John J Kyncl