Chemocentryx, Inc.

John J Kim Wright

Penglie Zhang

Wei Yu Chen

Andrew M K Pennell

Lianfa Li

Manmohan Reddy Leleti

Yandong Li

Yuan Xu

Kevin Lloyd Greenman

Yibin Zeng

Mark M Gleason

Anita Melikian

Edward J Sullivan

Wei Chen

Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

Azaindazole compounds and methods of use

Provided are methods for the treatment of rheumatoid arthritis using compounds of formula Ia and Ib: or a pharmaceutically acceptable salt, hydrate or N-oxide thereof.

Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally monocyclic and bicyclic compounds and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

Monocyclic and bicyclic compounds and methods of use

Methods are provided for the synthesis of 1-[4-(substituted phenyl)-piperazin-1-yl ] -2- [3-(1H-imidazol-2-yl)-pyrazolo [3,4-b]pyridin-1-yl]-ethanone compounds via construction of the imidazole portion onto the corresponding aldehyde or nitrile compounds.

Substituted benzamide compounds are provided along with methods for the use of those compounds for treating cancer. 

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Redwood City, CA, United States of America

John J Kim Wright