Adolor Corporation

Adolor Coporation

Apolor Corp.

John J Farrar

Virendra Kumar

An-Chih Chang

Alan L Maycock

Wei Yuan Zhang

Lawrence I Kruse

Diane L DeHaven-Hudkins

Michael Anthony Marella

Forrest Gaul

Alan Cowan

Imre Jim Balogh

William K Schmidt

Peter J Schied

Randall L Carpenter

Imre (Jim) Balogh

Diane L Dehaven-Hudkins

Imre Balogh

Methods for the treatment of ileus are disclosed wherein the peripheral mu opioid antagonist methylnaltrexone is administered.

Methods for the treatment or inhibition of ileus

Compounds having kappa opioid agonist activity, compositions containing them and 5 method of using them as analgesics and pruritic agents are provided. The compounds of formulae I, II, III and IV have the structure: wherein

Kappa agonist compounds and pharmaceutical formulations thereof

Methods for prevention or treatment of pruritus are provided. The methods comprise administering to a patient an effective amount of a kappa opioid receptor agonist compound. The involved kappa opioid receptor agonist compounds are of the type represented by the following formula III

Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith

Methods for the treatment and/or prevention of ileus are disclosed. The methods comprise administering to a patient an effective amount of a peripheral mu opioid antagonist compound. Preferred compounds for use in the methods include piperidine-N-alkylcarboxylates.

Methods for the treatment and prevention of ileus

Novel methods and compositions comprising opioids and opioid antagonists. In preferred embodiments, the methods and compositions comprise opioids and peripheral mu opioid antagonist compounds. The methods and compositions are particularly suitable for treating and/or preventing side effects associated with opioids including, for example, constipation, vomiting and/or nausea.

Methods and compositions involving opioids and antagonists thereof

Peripherally acting anti-pruritic opiates

Anti-pruritic pharmaceutical formulations containing kappa agonist compounds and methods of prevention or treatment of pruritus in a mammal with the anti-pruritic formulations.

Kappa agonist anti-pruritic pharmaceutical formulations and method of

Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided. The compounds of formula III having the structure: ##STR1## wherein Ar and X.sup.7 ;

Kappa agonist compounds, pharmaceutical formulations and method of

Kappa agonist anti-pruritic pharmaceutical formulaitons and method of

Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided. The compounds of formula II having the structure: ##STR1## wherein X.sub.4, X.sub.5 ;

Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compound of formulae IV having the structure: ##STR1## wherein X.sub.9 ;

Topical film-forming compositions for the prevention and treatment of prutitus containing an opiate that is substantially devoid of central nervous system effects.

Growing community of inventors

Chester Springs, PA, United States of America

John J Farrar