Customarray, Inc.

Combimatrix Corporation

John J Cooper, Jr

Karl Maurer

Kristian M Roth

Joseph Leonetti

H Sho Fujii

H Sho Fuji

Kilian Dill

Michael Strathmann

Andrei Ghindilis

Karl Mauer

There is disclosed an electrode array architecture employing continuous and discontinuous circumferential electrodes. There is further disclosed a process for the neutralization of acid generated at anode(s) by base generated at cathode(s) circumferentially located to each other so as to confine a region of pH change. The cathodes can be displayed as concentric rings (continuous) or as counter electrodes in a cross pattern (discontinuous). In this way reagents, such as acid, generated in a center electrode are countered (neutralized) by reagents, such as base, generated at the corners or at the outer ring.

Neutralization and containment of redox species produced by circumferential electrodes

There is disclosed an electrochemical deblocking solution for use on an electrode microarray. There is further disclosed a method for electrochemical synthesis on an electrode array using the electrochemical deblocking solution. The solution and method are for removing acid-labile protecting groups for synthesis of oligonucleotides, peptides, small molecules, or polymers on a microarray of electrodes while substantially improving isolation of deblocking to active electrodes. The method comprises applying a voltage or a current to at least one electrode of an array of electrodes. The array of electrodes is covered by the electrochemical deblocking solution.

Electrochemical deblocking solution for electrochemical oligomer synthesis on an electrode array

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Seattle, WA, United States of America

John J Cooper, Jr