Flagship Pioneering Innovations Vi, LLC

John Ingraham

Gevorg Grigoryan

Cheuk Lun Leung

Alexis Hiram Ramos

Ross Steven Federman

Robin Jeffrey Green

Jenhan Tao

Vincent Xue

Craig Owen Mackenzie

Antigen Binding Molecules Targeting SARS-CoV-2

The invention provides, in various embodiments, polypeptides (e.g., camelid antibodies and antigen binding fragments thereof) that specifically bind to Spike glycoprotein of severe acute respiratory syndrome coronavirus (e.g., SARS-CoV-2-Spike). The invention also provides, in various embodiments, fusion proteins comprising one or more of the polypeptides, polynucleotides encoding the polypeptides, vectors and host cells suitable for expressing the polypeptides, and methods for treating viral infections (e.g., COVID-19).

Antigen binding molecules targeting SARS-CoV-2

The invention provides, in various embodiments, polypeptides that specifically bind to Spike glycoprotein of severe acute respiratory syndrome coronavirus (e.g., SARS-CoV-2-Spike). The invention also provides, in various embodiments, fusion proteins comprising one or more of the polypeptides, polynucleotides encoding the polypeptides, vectors and host cells suitable for expressing the polypeptides, and methods for treating viral infections (e.g., COVID-19).

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Cambridge, MA, United States of America

John Ingraham